ArticleCNS neuroscience & therapeutics2021
Characteristics and outcome-related factors of seizure at the first onset of autoimmune encephalitis: A retrospective study.
Article in CNS neuroscience & therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.
- Does the Use of Intravenous Immunoglobulin Improve Clinical Outcomes in Adults With Autoimmune Encephalitis? A Systematic Review.Brain and behavior · 2025Pooled it
- Seizure outcome-related factors in autoimmune encephalitis: A systematic review and meta-analysis.Frontiers in neurology · 2022Pooled it
- Epileptic spasms in the acute phase of pediatric anti-N-methyl-d-aspartate receptor encephalitis: a case series.Frontiers in immunology · 2026Article
- Acute Symptomatic Seizures and Risk of Seizure Recurrence in Patients with Anti-NMDAR, Anti-LGI1, and Anti-GABANeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Article
- Efficacy of tocilizumab in anti- N -methyl-d-asparate receptor encephalitis with Graves' hyperthyroidism and positive anti-glial fibrillary acidic protein antibodies.CNS neuroscience & therapeutics · 2022Article
- Factors predicting neuronal surface antibodies in the elderly with new-onset and unknown seizures.Annals of clinical and translational neurology · 2022Article
- Acute Symptomatic Seizures and Risk of Epilepsy in Autoimmune Encephalitis: A Retrospective Cohort Study.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsSeizure outcome of autoimmune encephalitis (AE) varies from seizure-free to refractory epilepsy, and the associated factors remain unclear. We aimed to describe seizure characteristics, identify seizure outcome-related factors, and discuss the medication strategy of antiepileptic drugs (AEDs) at the first onset of AE.
methodsWe retrospectively studied the data of 86 patients with clinically diagnosed AE. The clinical characteristics were described using a chi-square test. Seizure outcome-related factors were assessed using multivariable logistic regression analysis.
results56 patients were finally enrolled, with antibodies to N-methyl-D-aspartate receptor found in 29, to γ-aminobutyric acid receptor B found in 13, and to leucine-rich glioma-inactivated protein 1 found in 14. Status epilepticus occurrence and onset with seizure lead to a poor seizure outcome, while administration of human gamma globulin and a low antibody titer contributed to a good seizure outcome.
conclusionsIn the acute phase, seizure characteristics may be considered in the utilization of AEDs. For patients with seizure-free status in the acute phase, clinical manifestation (onset with seizure or not, whether status epilepticus occurs or not), therapy regimen (human gamma globulin administered or not), and antibody titer may be considered when formulating the strategy for withdrawal of AEDs post-acute phase.
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