Evidence map›Paper›PMID 33683641›Full record

ArticleSpine deformity2021

Vitamin D levels and pain outcomes in adolescent idiopathic scoliosis patients undergoing spine fusion.

Alexandra Beling, M Timothy Hresko, Leah DeWitt, Patricia E Miller, Sarah A Pitts, John B Emans, Daniel J Hedequist, Michael P Glotzbecker

Abstract read
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In one paragraph

Article in Spine deformity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alexandra BelingDepartment of Orthopedics, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA.ORCID 0000-0003-3339-8679
M Timothy HreskoDepartment of Orthopedics, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA.
Leah DeWittDepartment of Orthopedics, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA.
Patricia E MillerDepartment of Orthopedics, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA.
Sarah A PittsDivision of Endocrinology, Boston Children's Hospital, Boston, MA, USA.
John B EmansDepartment of Orthopedics, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA.
Daniel J HedequistDepartment of Orthopedics, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA.
Michael P GlotzbeckerDepartment of Orthopedics, University Hospitals Cleveland Medical Center, 11100 Euclid Ave, Cleveland, OH, 44106, USA. Michael.Glotzbecker@UHhospitals.org.
Boston Children's Hospital · USUniversity Hospitals of Cleveland · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePrior research has indicated adolescent idiopathic scoliosis (AIS) patients have lower bone mineral density and lower vitamin D levels than healthy peers. Vitamin D deficiency has been associated with higher levels of pain. This study investigated whether vitamin D-deficient AIS patients had higher pain before or immediately after posterior spine fusion (PSF) surgery.

methods25-Hydroxy vitamin D levels were tested in all AIS patients at their pre-operative appointment. Patients were grouped by serum 25-hydroxy vitamin D level: deficient, < 20 ng/mL; insufficient, 20-29 ng/mL; sufficient, ≥ 30 ng/mL. Primary outcomes included pre-operative Scoliosis Research Society Health-Related Quality of Life (SRS-30) and numeric rating scale (NRS) scores (0-10) up to 72 h post-operatively, and analyzed using ANOVA and linear mixed modeling, respectively. 176 patients undergoing PSF were included. Intra-operative characteristics by vitamin D status were also assessed. The cohort was 82% female and an average of 15.2 years (range 10.6-25.3 years) at fusion. Average major curve was 60 (range 40-104) degrees pre-operatively.

resultsForty-five (26%) patients were deficient in vitamin D, 75 (43%) were insufficient, and 56 (32%) were sufficient. Patients with vitamin D deficiency had lower average household income by zip code (p < 0.01) and higher secondhand smoke exposure (p < 0.001). There were no differences in pre-operative SRS-30 score, pre- and post-operative major curve angles, or estimated blood loss across vitamin D groups. Trajectories of NRS indicated no differences in pain during the first 72 h after surgery.

conclusionVitamin D deficiency in this population is associated with potential markers of lower socioeconomic status; however, it does not influence AIS PSF patients' experience of pain before or immediately after spine fusion surgery. LEVEL OF EVIDENCE: II.

Indexed as

ScoliosisSpinal FusionAdolescentFemaleHumansMalePainQuality of LifeVitamin DVitamin DAdolescentPainQuality of lifeScoliosisVitamin D deficiency

Identifiers

PMID33683641
OpenAlexW3135341256

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.