ArticleEnvironmental science and pollution research international2021
The sex-specific association between maternal urinary paraben levels and offspring size at birth.
Article in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- A systematic review of the toxic potential of parabens in fish.Frontiers in toxicology · 2024Pooled it
- Association of maternal height with pregnancy complications: Analyses of two cohorts.Pregnancy (Hoboken, N.J.) · 2026Article
- Monitoring of urinary nickel and chromium in metal industries workers in Alborz, Iran.Scientific reports · 2024Article
- Association between type of drinking water and upper gastrointestinal cancer incidence in the Linxian General Population.BMC cancer · 2023Article
- Article
- Association between urinary phthalate levels and chronic pain in US adults, 1999-2004: A nationally representative survey.Frontiers in neurology · 2023Article
- Maternal diet quality moderates associations between parabens and birth outcomes.Environmental research · 2022Article
- The association of prenatal exposure to benzophenones with gestational age and offspring size at birth.Environmental science and pollution research international · 2022Article
- Concentrations of urinary parabens and reproductive hormones in Iranian women: Exposure and risk assessment.Toxicology reports · 2022Article
- Interventions on Reducing Exposure to Endocrine Disrupting Chemicals in Human Health Care Context: A Scoping Review.Risk management and healthcare policy · 2022Article
- Monitoring of urinary arsenic (As) and lead (Pb) among a sample of pregnant Iranian women.Journal of environmental health science & engineering · 2021Article
- Prenatal exposure to chromium (Cr) and nickel (Ni) in a sample of Iranian pregnant women: urinary levels and associated socio-demographic and lifestyle factors.Environmental science and pollution research international · 2021Article
- Association between prenatal phthalate exposure and anthropometric measures of newborns in a sample of Iranian population.Environmental science and pollution research international · 2021Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Parabens are a group of antimicrobial preservatives applied in an extensive range of products and are suspected to impair fetal growth because of their disrupting effect on the endocrine system. We aimed to examine maternal urinary paraben concentrations and their neonates' outcome indexes. Methylparaben (MP), ethylparaben (EP), propylparaben (PP), and butylparaben (BP) concentrations were measured in 105 maternal urine samples collected before delivery. Length, weight, and head circumference at birth were extracted from the mothers' delivery files. A multivariable linear regression analysis was performed to evaluate the association between paraben levels and neonatal anthropometric indices. The median levels of urinary parabens, especially BP, were higher than those in other countries. Prenatal urinary concentration of MP and BP showed a significantly positive association with birth weight in all neonates (β = 0.79, 95% CI: 0.16, 1.41, and β = 8.56, 95% CI: 3.95, 13.17, respectively), while these chemicals showed a significant negative association with head circumference (β = - 0.002, 95% CI: - 0.004, - 0.000, and β = - 0.016, 95% CI: - 0.030, - 0.002, respectively). A significant positive association between MP and birth length was also found (β = 0.004, 95% CI: 0.00, 0.00) in all the neonates. In sex-stratified adjusted models, MP and BP were found to be associated, respectively, with higher birth length and weight in male neonates (β = 0.008, 95% CI: - 0.001, 0.017, and β = 7.948, 95% CI: 1.045, 14.851). In girls, maternal urinary MP, PP, and BP were associated with increased birth weight (β = 0.831, 95% CI: 0.043, 1.620; β = 4.178, 95% CI: 0.877, 7.480; and β = 10.821, 95% CI: 3.545, 18.097, respectively), and MP and BP were associated with reduced head circumference at birth (β = - 0.003, 95% CI: - 0.005, - 0.001, and β = - 0.035, 95% CI: - 0.055, - 0.016). These results revealed potential impacts between neonatal growth and maternal exposure to parabens. However, these findings should be interpreted while considering the limitations of the present study.
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