Evidence map›Paper›PMID 33683528›Full record

SynthesisBrain imaging and behavior2021

Resting-state abnormalities in functional connectivity of the default mode network in autism spectrum disorder: a meta-analysis.

Qing Wang, Hua-Yun Li, Yun-Da Li, Ya-Ting Lv, Hui-Bin Ma, An-Feng Xiang, Xi-Ze Jia, Dong-Qiang Liu

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Aberrant type 2 dopamine and mu-opioid receptor availability in autism spectrum disorder.European journal of nuclear medicine and molecular imaging · 2026
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  8. Causal relationships between neuroimaging phenotypes and the risk of early and late-onset alzheimer's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qing WangResearch Center of Brain and Cognitive Neuroscience, Liaoning Normal University, Dalian, China.
Hua-Yun LiCollege of Teacher Education, Zhejiang Normal University, Jinhua, China.
Yun-Da LiSchool of Information and Electronics Technology, Jiamusi University, Jiamusi, China.
Ya-Ting LvInstitute of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.
Hui-Bin MaSchool of Information and Electronics Technology, Jiamusi University, Jiamusi, China.
An-Feng XiangTongji University School of Medicine, Shanghai, China.
Xi-Ze JiaInstitute of Psychological Sciences, Hangzhou Normal University, Hangzhou, China. jiaxize@hznu.edu.cn.ORCID http://orcid.org/0000-0001-8374-5582
Dong-Qiang LiuResearch Center of Brain and Cognitive Neuroscience, Liaoning Normal University, Dalian, China. charlesliu116@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence has shown that the resting state brain connectivity of default mode network (DMN) which are important for social cognition are disrupted in autism spectrum disorder (ASD). However, previous neuroimaging studies did not present consistent results. Therefore, we performed a meta-analysis of resting-state functional connectivity (rsFC) studies of DMN in the individuals with ASD and healthy controls (HCs) to provide a new perspective for investigating the pathophysiology of ASD. We carried out a search using the terms: ("ASD" OR "Autism") AND ("resting state" OR "rest") AND ("DMN" OR "default mode network") in PubMed, Web of Science and Embase to identify the researches published before January 2020. Ten resting state datasets including 203 patients and 208 HCs were included. Anisotropic Effect Size version of Signed Differential Mapping (AES-SDM) method was applied to identify group differences. In comparison with the HCs, the patients with ASD showed increased connectivity in cerebellum, right middle temporal gyrus, superior occipital gyrus, right supramarginal gyrus, supplementary motor area and putamen. Decreased connectivity was discovered in some nodes of DMN, such as medial prefrontal cortex, precuneus and angular gyrus. These results may help us to further clarify the neurobiological mechanisms in patients with ASD.

Indexed as

Autism Spectrum DisorderBrainBrain MappingDefault Mode NetworkHumansMagnetic Resonance ImagingNeural PathwaysRestAutism spectrum disorderDefault mode networkFunctional connectivityMeta‐analysisResting state

Identifiers

PMID33683528

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.