Evidence map›Paper›PMID 33683527›Full record

ArticleAnnals of biomedical engineering2021

Quantifying the Effects of Aging on Morphological and Cellular Properties of Human Female Pelvic Floor Muscles.

Mary Rieger, Pamela Duran, Mark Cook, Simon Schenk, Manali Shah, Marni Jacobs, Karen Christman, Deborah M Kado, Marianna Alperin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Mary Rieger *Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0863, USA.
Pamela Duran *Department of Bioengineering and Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, USA.
Mark Cook *Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, USA.
Simon SchenkDepartment of Orthopedic Surgery, University of California San Diego, La Jolla, USA.
Manali ShahDepartment of Bioengineering, University of California San Diego, La Jolla, USA.
Marni JacobsDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, La Jolla, USA.
Karen ChristmanDepartment of Bioengineering and Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, USA.
Deborah M KadoHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, USA.
Marianna AlperinDivision of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0863, USA. malperin@health.ucsd.edu.
University of California, San Diego · USLa Jolla Bioengineering Institute · USSanford Consortium for Regenerative Medicine · USUniversity of Minnesota · US

Funding

UC San Diego Womens Reproductive Health Research ProgramK12HD001259 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CYNTHIA GYAMFI-BANNERMAN · 1999 to 2026
$9.1M
Mechanisms and Impact of Pregnancy-Induced Adaptations in Pelvic Floor MusclesR01HD092515 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALPERIN, MARIANNA · 2017 to 2025
$4.0M
Prevention of pelvic floor muscle dysfunction with extracellular matrix hydrogelR01HD102184 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALPERIN, MARIANNA, CHRISTMAN, KAREN L · 2020 to 2024
$3.2M
Injectable Tissue-Specific Extracellular Matrix Hydrogel for Pelvic Skeletal Muscle Regeneration Following Birth InjuryR21HD094566 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALPERIN, MARIANNA, CHRISTMAN, KAREN L · 2018 to 2019
$426k
Impact of Aging on Structure and Function of Pelvic Floor MusclesR03AG050951 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALPERIN, MARIANNA · 2016 to 2017
$233k
Architectural Design of the Pelvic Floor Skeletal MusclesR03HD075994 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALPERIN, MARIANNA · 2013 to 2014
$153k
Prevention of Urethral and Anal Sphincters Dysfunction with an Acellular BiomaterialF31HD098007 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DURAN, PAMELA · 2019 to 2020
$75k
National Institute of Child Health and Human Development F31HD098007National Institute of Child Health and Human Development R01HD092515National Institute of Child Health and Human Development R01HD102184National Institute of Child Health and Human Development R21HD094566NIA NIH HHS R03 AG050951NIA NIH HHS R03HDO75994NICHD NIH HHS F31 HD098007NICHD NIH HHS K12 HD001259NICHD NIH HHS R01 HD092515NICHD NIH HHS R01 HD102184NICHD NIH HHS R03 HD075994NICHD NIH HHS R21 HD094566
6 · The paper itself

Abstract

Age-related pelvic floor muscle (PFM) dysfunction is a critical defect in the progression to pelvic floor disorders (PFDs). Despite dramatic prevalence of PFDs in older women, the underlying pathophysiology of age-related PFM dysfunction remains poorly understood. Using cadaveric specimens, we quantified aging effects on functionally relevant PFM properties and compared PFMs with the appendicular muscles from the same donors. PFMs, obturator internus, and vastus lateralis were procured from younger (N = 4) and older (N = 11) donors with known obstetrical and medical history. Our findings demonstrate that PFMs undergo degenerative, rather than atrophic, alterations. Importantly, age-related fibrotic degeneration disproportionally impacts PFMs compared to the appendicular muscles. We identified intramuscular lipid accumulation as another contributing factor to the pathological alterations of PFMs with aging. We observed a fourfold decrease in muscle stem cell (MuSC) pool of aged relative to younger PFMs, but the MuSC pool of appendicular muscles from the same older donors was only twofold lower than in younger group, although these differences were not statistically significant. Age-related degeneration appears to disproportionally impact PFMs relative to the appendicular muscles from the same donors. Knowledge of tissue- and cell-level changes in aged PFMs is essential to promote our understanding of the mechanisms governing PFM dysfunction in older women.

Indexed as

Muscle ContractionMuscle, SkeletalPelvic FloorAdultAgedAged, 80 and overAgingFemaleHumansMiddle AgedAgingFemalePelvic floor disordersPelvic floor muscles

Identifiers

PMID33683527
PMCPMC8376748
OpenAlexW3135728237

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.