ArticleThe European physical journal. E, Soft matter2021
First passage time in post-transcriptional regulation by multiple small RNAs.
Article in The European physical journal. E, Soft matter, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Decoupling between activation time and steady-state level in input-output responses.PLoS computational biology · 2026Article
- Decoupling between activation time and steady-state level in input-output responses.bioRxiv : the preprint server for biology · 2025Article
- Sequestration of gene products by decoys enhances precision in the timing of intracellular events.Scientific reports · 2024Article
- A stochastic vs deterministic perspective on the timing of cellular events.Nature communications · 2024Article
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Authors and funding
2 authors.
Funding
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Abstract
The post-transcriptional regulation of a protein by multiple small RNA molecules has been formulated as a stochastic process. An approximate solution of the master equation shows that the protein statistics can exhibit a generic form applicable for many regulatory scenarios. The first passage time (FPT) statistics has been obtained for regulation by single sRNA, with negative and positive regulations as limiting cases, as well as regulation by multiple sRNAs. The multiple sRNAs are able to independently control protein mean and variance, and we show that this is an advantageous mechanism to control FPT fluctuations in order to improve timing efficiency in post-transcriptional regulation.
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