ArticleeLife2021
Multiple time-scales of decision-making in the hippocampus and prefrontal cortex.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
65 citing papers in PubMed, 115 citations in OpenAlex.
- Anxiety sensitivity and intolerance of uncertainty track distinct neurobehavioral dimensions of avoidance in anxiety-related disorders.Molecular psychiatry · 2026Article
- Just how goal-directed are hippocampal theta sweeps, anyway?Nature neuroscience · 2026Article
- Decoding Medial Entorhinal Cortical Dynamics Produces Planning-Like Alternations in Hippocampal theta Sequences.Hippocampus · 2026Article
- Goal-directed hippocampal theta sweeps during memory-guided navigation.Nature neuroscience · 2026Article
- Hippocampal engrams configure prefrontal context representations to guide flexible decisions.bioRxiv : the preprint server for biology · 2026Article
- Neural timescales from a computational perspective.Nature neuroscience · 2026Review
- Distinct goal location beta frequency dynamics in hippocampus and prefrontal cortex across learning.bioRxiv : the preprint server for biology · 2026Article
- Cross-frequency coordination in a hippocampo-cortical circuit during probabilistic reversal learning.Communications biology · 2026Article
- Independence and coherence in temporal sequence computation across the fronto-parietal network.Nature communications · 2026Article
- The Neuroscience of Decision-Making: Linking the Brain, Behavior, and Society.Brain sciences · 2026Article
- Flexible goal learning involves coordinated population activity in dCA1 and medial orbitofrontal cortex.PLoS biology · 2026Article
- Article
- Differential representations of spatial environments in mPFC and hippocampus underpinning flexible navigation.NeuroImage · 2026Article
- Resonant hierarchies: a multiscale framework for oscillatory dynamics in the brain.Frontiers in psychology · 2026Article
- Prefrontal Default Mode Network Interactions with Posterior Hippocampus during Exploration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Stimulation of CaScience signaling · 2025Article
- Hippocampal pyramidal cells of the CA1 region are not a major target of the thalamic nucleus reuniens.PLoS biology · 2025Article
- Hippocampal-Prefrontal Communication Subspaces Align with Behavioral and Network Patterns in a Spatial Memory Task.eNeuro · 2025Article
- Disruption of hippocampal-prefrontal neural dynamics and risky decision-making in a mouse model of Alzheimer's disease.Cell reports · 2025Article
- Theta-encoded information flow from dorsal CA1 to prelimbic cortex drives memory reconsolidation.iScience · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The prefrontal cortex and hippocampus are crucial for memory-guided decision-making. Neural activity in the hippocampus exhibits place-cell sequences at multiple timescales, including slow behavioral sequences (~seconds) and fast theta sequences (~100-200 ms) within theta oscillation cycles. How prefrontal ensembles interact with hippocampal sequences to support decision-making is unclear. Here, we examined simultaneous hippocampal and prefrontal ensemble activity in rats during learning of a spatial working-memory decision task. We found clear theta sequences in prefrontal cortex, nested within its behavioral sequences. In both regions, behavioral sequences maintained representations of current choices during navigation. In contrast, hippocampal theta sequences encoded alternatives for deliberation and were coordinated with prefrontal theta sequences that predicted upcoming choices. During error trials, these representations were preserved to guide ongoing behavior, whereas replay sequences during inter-trial periods were impaired prior to navigation. These results establish cooperative interaction between hippocampal and prefrontal sequences at multiple timescales for memory-guided decision-making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.