Evidence map›Paper›PMID 33683123›Full record

ArticleJournal of proteome research2021

Human Bone Proteomes before and after Decomposition: Investigating the Effects of Biological Variation and Taphonomic Alteration on Bone Protein Profiles and the Implications for Forensic Proteomics.

Hayley L Mickleburgh, Edward C Schwalbe, Andrea Bonicelli, Haruka Mizukami, Federica Sellitto, Sefora Starace, Daniel J Wescott, David O Carter, Noemi Procopio

Open access · hybridAbstract read
In one paragraph

Article in Journal of proteome research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
54.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Pooled it
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  3. "Omics" and Postmortem Interval Estimation: A Systematic Review.International journal of molecular sciences · 2025
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  9. Review
  10. Forensic Proteomics for the Discovery of NewInternational journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Hayley L MickleburghDepartment of Cultural Sciences, Linnaeus University, Kalmar 352 52, Sweden.
Edward C SchwalbeForensic Science Research Group, Faculty of Health and Life Sciences, Northumbria University, Ellison Building, Northumbria University Newcastle, Newcastle Upon Tyne NE1 8ST, U. K.
Andrea BonicelliForensic Science Research Group, Faculty of Health and Life Sciences, Northumbria University, Ellison Building, Northumbria University Newcastle, Newcastle Upon Tyne NE1 8ST, U. K.
Haruka MizukamiForensic Science Research Group, Faculty of Health and Life Sciences, Northumbria University, Ellison Building, Northumbria University Newcastle, Newcastle Upon Tyne NE1 8ST, U. K.
Federica SellittoForensic Science Research Group, Faculty of Health and Life Sciences, Northumbria University, Ellison Building, Northumbria University Newcastle, Newcastle Upon Tyne NE1 8ST, U. K.
Sefora StaraceDipartimento di Chimica, University of Turin, Via P. Giuria 7, 10125 Turin, Italy.
Daniel J WescottForensic Anthropology Center, Texas State University, San Marcos 78666, Texas, United States.
David O CarterForensic Sciences Unit, School of Natural Sciences and Mathematics, Chaminade University of Honolulu, Honolulu 96816, Hawaii, United States.
Noemi ProcopioForensic Science Research Group, Faculty of Health and Life Sciences, Northumbria University, Ellison Building, Northumbria University Newcastle, Newcastle Upon Tyne NE1 8ST, U. K.ORCID 0000-0002-7461-7586
Northumbria University · GBTexas State University · USChaminade University of Honolulu · USUniversity of Turin · IT

Funding

Medical Research Council MR/S032878/1
6 · The paper itself

Abstract

Bone proteomic studies using animal proxies and skeletonized human remains have delivered encouraging results in the search for potential biomarkers for precise and accurate post-mortem interval (PMI) and the age-at-death (AAD) estimation in medico-legal investigations. The development of forensic proteomics for PMI and AAD estimation is in critical need of research on human remains throughout decomposition, as currently the effects of both inter-individual biological differences and taphonomic alteration on the survival of human bone protein profiles are unclear. This study investigated the human bone proteome in four human body donors studied throughout decomposition outdoors. The effects of ageing phenomena (

Indexed as

ProteomeProteomicsAnimalsAutopsyBone and BonesHumansPostmortem ChangesProteomeage-at-death estimationbone mineral densityforensic microbiologyforensic proteomicsforensic taphonomyhuman decompositionpost-mortem interval estimation

Identifiers

PMID33683123
PMCPMC8155572
OpenAlexW3134683585

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.