Evidence map›Paper›PMID 33682938›Full record

ArticleNMR in biomedicine2021

Carbonic anhydrase activity in the frontal lobe of human brain.

Shizhe Li, Li An, Maria Ferraris Araneta, Milalynn Victorino, Christopher S Johnson, Jun Shen

Open access · greenAbstract read
In one paragraph

Article in NMR in biomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Structural Studies of the Dopamine DACS medicinal chemistry letters · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shizhe LiNational Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-7086-6753
Li AnNational Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Maria Ferraris AranetaNational Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Milalynn VictorinoNational Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Christopher S JohnsonNational Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Jun ShenNational Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
National Institutes of Health · US

Funding

Magnetic Resonance Spectroscopy and Imaging Studies of Brain FunctionsZIAMH002803 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI SHEN, JUN · 2009 to 2025
$24.9M
Magnetic Resonance Spectroscopy Core FacilityZICMH002894 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI SHEN, JUN · 2009 to 2024
$13.5M
Intramural NIH HHS Z99 MH999999Intramural NIH HHS ZIA MH002803Intramural NIH HHS ZIC MH002894
6 · The paper itself

Abstract

Carbonic anhydrase (CA) plays an important role in many biological processes. Recent technological advances have demonstrated the feasibility of measuring CA activity in the occipital lobe of human subjects in vivo. In this work we report, for the first time, in vivo measurement of CA activity in the frontal lobe of human brain, where structural and function abnormalities are strongly associated with symptoms of major psychiatric disorders. Despite the much larger magnetic field distortion in the frontal lobe, the pseudo first-order bicarbonate dehydration rate constant was determined with high precision using in vivo

Indexed as

Amino AcidsBicarbonatesCarbon-13 Magnetic Resonance SpectroscopyCarbonic AnhydrasesFrontal LobeHumansKineticsLactic AcidOccipital LobeRadio WavesTime FactorsAmino AcidsBicarbonatesCarbonic AnhydrasesLactic Acid13C MRScarbonic anhydrasefrontal lobe

Identifiers

PMID33682938
PMCPMC10158825
OpenAlexW3135503647

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.