Evidence map›Paper›PMID 33682887›Full record

Trial reportRheumatology (Oxford, England)2021

Medication adherence in older people with rheumatoid arthritis is lower according to electronic monitoring than according to pill count.

Linda Hartman, Maurizio Cutolo, Reinhard Bos, Daniela Opris-Belinski, Marc R Kok, Hanneke J R M Griep-Wentink, Ruth Klaasen, Cornelia F Allaart, George A W Bruyn, Hennie G Raterman and 6 more

Registry-linked trialOpen access · hybridAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Rheumatology (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02585258 (The Glucocorticoid Low-dose Outcome in RheumatoId Arthritis Study Comparing the Cost-effectiveness and Safety of Additional Low-dose Glucocorticoid in Treatment Strategies for Elderly Patients With Rheumatoid Arthritis), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02585258 phase4completednot on this map

The Glucocorticoid Low-dose Outcome in RheumatoId Arthritis Study Comparing the Cost-effectiveness and Safety of Additional Low-dose Glucocorticoid in Treatment Strategies for Elderly Patients With Rheumatoid Arthritis

TypeinterventionalSponsorAmsterdam UMC, location VUmcRan2016 to 2020Enrolled451ConditionsRheumatoId ArthritisArmsPrednisolone, Placebo
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 3 countries.

Linda HartmanAmsterdam Rheumatology and Immunology Center, Amsterdam UMC, Location VUmc.ORCID 0000-0003-4583-962X
Maurizio CutoloDepartment of Rheumatology, University of Genoa, Genoa, Italy.
Reinhard BosDepartment of Rheumatology, Medical Center Leeuwarden, Leeuwarden, The Netherlands.
Daniela Opris-BelinskiDepartment of Internal Medicine and Rheumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Marc R KokDepartment of Rheumatology and Clinical immunology, Maasstad Hospital, Rotterdam.
Hanneke J R M Griep-WentinkDepartment of Rheumatology, Antonius Hospital, Sneek.
Ruth KlaasenDepartment of Rheumatology, Meander Medical Center, Amersfoort.
Cornelia F AllaartDepartment of Rheumatology, Leids University Medical Center, Leiden.
George A W BruynDepartment of Rheumatology, Reumakliniek Flevoland, Lelystad.ORCID 0000-0001-7020-5798
Hennie G RatermanDepartment of Rheumatology, Northwest Clinics, Alkmaar.
Marieke J H VoshaarDepartment of Pharmacy, Radboud University, Nijmegen.
Nuno GomesExatronic, Aveiro, Portugal.
Rui M A PintoBluepharma, Indústria Farmacêutica, S.A, Coimbra, Portugal.
L Thomas KlauschEpidemiology & Data Science, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
Willem F LemsAmsterdam Rheumatology and Immunology Center, Amsterdam UMC, Location VUmc.
M BoersAmsterdam Rheumatology and Immunology Center, Amsterdam UMC, Location VUmc.ORCID 0000-0002-6969-283X
Amsterdam University Medical Centers · NLAmsterdam UMC Location Vrije Universiteit Amsterdam · NLCarol Davila University of Medicine and Pharmacy · ROLeiden University Medical Center · NLMaasstad Ziekenhuis · NLMeander Medisch Centrum · NLMedisch Centrum Leeuwarden · NLRadboud University Nijmegen · NLSt. Antonius Ziekenhuis · NLUniversity of Genoa · IT

Funding

European Union's Horizon 2020Personalizing Health and Care 634886
6 · The paper itself

Abstract

objectivesSuboptimal medication adherence is a serious problem in the treatment of chronic inflammatory diseases. To measure medication adherence, electronic monitoring is regarded as superior to pill count. GLORIA is an ongoing two-year trial on the addition of low-dose (5 mg/d) prednisolone or placebo to standard care in older people (65+ years) with RA. During the entire trial, adherence is measured with electronic caps, and with pill counts. The objective is to describe medication adherence patterns, and to compare the adherence results of the two methods.

methodsThe recorded adherence patterns of patients (blinded for treatment group) were classified according to descriptive categories. The cutoff for good adherence was set at 80% of prescribed pills taken.

resultsTrial inclusion closed in 2018 at 451 patients, but trial follow-up is ongoing; the current dataset contains adherence data of 371 patients. Mean number of recorded 90-day periods per patient was 4 (range 1-8). Based on pill count over all periods, 90% of the patients had good adherence; based on cap data, only 20%. Cap data classified 30% of patients as non-user (<20% of days an opening) and 40% as irregular user (different adherence patterns, in or between periods).

conclusionIn our trial of older people with RA, the majority appeared to be adherent to medication according to pill count. Results from caps conflicted with those of pill counts, with patterns suggesting patients did not use the bottle for daily dispensing, despite specific advice to do so.

trial registrationNCT02585258. ClinicalTrials.gov (https://www.clinicaltrials.gov/).

Indexed as

Drug MonitoringAgedAged, 80 and overArthritis, RheumatoidDrug PackagingFemaleGlucocorticoidsHumansMalePrednisoloneGlucocorticoidsPrednisoloneelectronic monitoringglucocorticoidsmedication adherencepill countrheumatoid arthritis

Identifiers

PMID33682887
PMCPMC8566247
OpenAlexW3135027531

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.