Evidence map›Paper›PMID 33682527›Full record

Trial reportAIDS care2023

Pilot study of tolerability and safety of opioid receptor antagonists as novel therapies for chronic pain among persons living with HIV with past year heavy drinking: a randomized controlled trial.

Sally Bendiks, Debbie M Cheng, Elena Blokhina, Marina Vetrova, Elena Verbitskaya, Natalia Gnatienko, Kendall Bryant, Evgeny Krupitsky, Jeffrey H Samet, Judith I Tsui

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03278886 (Pilot Study of Opioid-receptor Antagonists to Reduce Pain and Inflammation Among HIV-Infected Persons With Alcohol Problems), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03278886 phase1 / phase2completednot on this map

Pilot Study of Opioid-receptor Antagonists to Reduce Pain and Inflammation Among HIV-Infected Persons With Alcohol Problems

TypeinterventionalSponsorBoston Medical CenterRan2018 to 2018Enrolled11ConditionsHIV Infection, Alcohol Use, PainArmsLow dose naltrexone, Nalmefene
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Review
  3. Alcohol Use Disorder and Chronic Pain: An Overlooked Epidemic.The American journal of psychiatry · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Sally BendiksDepartment of Medicine, Section of General Internal Medicine, Boston Medical Center, Clinical Addiction Research and Education (CARE) Unit, Boston, MA, USA.
Debbie M ChengDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Elena BlokhinaLab of Clinical Pharmacology of Addictions, First Pavlov State Medical University of St. Petersburg, St. Petersburg, Russia.
Marina VetrovaLab of Clinical Pharmacology of Addictions, First Pavlov State Medical University of St. Petersburg, St. Petersburg, Russia.
Elena VerbitskayaLab of Clinical Pharmacology of Addictions, First Pavlov State Medical University of St. Petersburg, St. Petersburg, Russia.
Natalia GnatienkoDepartment of Medicine, Section of General Internal Medicine, Boston Medical Center, Clinical Addiction Research and Education (CARE) Unit, Boston, MA, USA.
Kendall BryantHIV/AIDS Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
Evgeny KrupitskyLab of Clinical Pharmacology of Addictions, First Pavlov State Medical University of St. Petersburg, St. Petersburg, Russia.
Jeffrey H SametDepartment of Medicine, Section of General Internal Medicine, Boston Medical Center, Clinical Addiction Research and Education (CARE) Unit, Boston, MA, USA.
Judith I TsuiDepartment of Medicine, Division of General Internal Medicine, University of Washington/Harborview Medical Center, Seattle, WA, USA.
First Pavlov State Medical University of St. Petersburg · RUBoston Medical Center · USBoston University · USHarborview Medical Center · USNational Institutes of Health · US

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH, DEBBIE M. CHENG · 1998 to 2026
$51.7M
URBAN ARCH (2/5) Biostatistics and Data Management Core (BDM)U24AA020779 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CHENG, DEBBIE M. · 2011 to 2020
$3.6M
URBAN ARCH (1/5) Administrative Coordinating Core (Admin Core)U24AA020778 · NIAAA · BOSTON MEDICAL CENTER · PI SAMET, JEFFREY H. · 2011 to 2020
$3.5M
Pilot Study of Opioid-receptor Antagonists to Reduce Pain and Inflammation among HIV-Infected Persons with Alcohol ProblemsUH3AA026193 · NIAAA · BOSTON MEDICAL CENTER · PI SAMET, JEFFREY H., TSUI, JUDITH · 2019 to 2021
$1.0M
Pilot Study of Opioid-receptor Antagonists to Reduce Pain and Inflammation among HIV-Infected Persons with Alcohol ProblemsUH2AA026193 · NIAAA · BOSTON MEDICAL CENTER · PI SAMET, JEFFREY H., TSUI, JUDITH · 2017 to 2018
$385k
NIAAA NIH HHS U24 AA020778NIAAA NIH HHS U24 AA020779NIAAA NIH HHS UH2 AA026193NIAAA NIH HHS UH3 AA026193NIAID NIH HHS P30 AI027757NIAID NIH HHS P30 AI042853
6 · The paper itself

Abstract

CLINICAL

trial registrationClinicalTrials.gov identifier: NCT03278886.

Indexed as

AlcoholismChronic PainHIV InfectionsHumansNaltrexoneNarcotic AntagonistsPilot ProjectsTreatment OutcomeNaltrexoneNarcotic AntagonistsalcoholHIVnalmefenenaltrexonePain

Identifiers

PMID33682527
PMCPMC8421451
OpenAlexW3133574408

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.