ArticleAngewandte Chemie (International ed. in English)2021
pH Feedback Lifecycles Programmed by Enzymatic Logic Gates Using Common Foods as Fuels.
Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Nature-Inspired Enzymatic Cascades: Emerging Strategies for Sustainable Chemistry.Molecules (Basel, Switzerland) · 2026Review
- Using a biocatalyzed reaction cycle for transient and pH-dependent host-guest supramolecular hydrogels.Journal of materials chemistry. B · 2024Article
- Exploring Emergent Properties in Enzymatic Reaction Networks: Design and Control of Dynamic Functional Systems.Chemical reviews · 2024Review
- Diffusion-Limited Processes in Hydrogels with Chosen Applications from Drug Delivery to Electronic Components.Molecules (Basel, Switzerland) · 2023Review
- Untethered Soft Microrobots with Adaptive Logic Gates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Memory, switches, and an OR-port through bistability in chemically fueled crystals.Nature communications · 2022Article
- Self-Regulating Colloidal Co-Assemblies That Accelerate Their Own Destruction via Chemo-Structural Feedback.Angewandte Chemie (International ed. in English) · 2022Article
- Controlling the lifetime of cucurbit[8]uril based self-abolishing nanozymes.Chemical science · 2022Article
- Dissipative Organization of DNA Oligomers for Transient Catalytic Function.Angewandte Chemie (International ed. in English) · 2022Article
- Feedback and Communication in Active Hydrogel Spheres with pH Fronts: Facile Approaches to Grow Soft Hydrogel Structures.Angewandte Chemie (International ed. in English) · 2021Article
- Dissipative operation of pH-responsive DNA-based nanodevices.Chemical science · 2021Article
- pH Feedback Lifecycles Programmed by Enzymatic Logic Gates Using Common Foods as Fuels.Angewandte Chemie (International ed. in English) · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Artificial temporal signaling systems, which mimic living out-of-equilibrium conditions, have made large progress. However, systems programmed by enzymatic reaction networks in multicomponent and unknown environments, and using biocompatible components remain a challenge. Herein, we demonstrate an approach to program temporal pH signals by enzymatic logic gates. They are realized by an enzymatic disaccharide-to-monosaccharide-to-sugar acid reaction cascade catalyzed by two metabolic chains: invertase-glucose oxidase and β-galactosidase-glucose oxidase, respectively. Lifetimes of the transient pH signal can be programmed from less than 15 min to more than 1 day. We study enzymatic kinetics of the reaction cascades and reveal the underlying regulatory mechanisms. Operating with all-food grade chemicals and coupling to self-regulating hydrogel, our system is quite robust to work in a complicated medium with unknown components and in a biocompatible fashion.
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