Evidence map›Paper›PMID 33682171›Full record

ArticleClinical transplantation2021

The association of post-operative delirium with patient-reported outcomes and mortality after lung transplantation.

Claire L DeBolt, Ying Gao, Nicole Sutter, Allison Soong, Lorriana Leard, Golden Jeffrey, Mary Ellen Kleinhenz, Daniel Calabrese, John Greenland, Aida Venado and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Claire L DeBoltDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-4467-095X
Ying GaoDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Nicole SutterDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Allison SoongDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Lorriana LeardDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Golden JeffreyDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Mary Ellen KleinhenzDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Daniel CalabreseDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-0596-3434
John GreenlandDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-1422-8367
Aida VenadoDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Steven R HaysDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Rupal ShahDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Jasleen KukrejaDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Binh TrinhDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Nicholas A KolaitisDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Vanja DouglasDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Joshua M DiamondDepartment of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Patrick SmithDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0002-6374-0298
Jonathan SingerDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-0224-7472

Funding

Frailty and patient centered outcomes in candidates for lung transplantationR01HL134851 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SINGER, JONATHAN PAUL · 2017 to 2021
$3.4M
The Effects of Lung Transplant on Disability and Health-Related Quality of LifeK23HL111115 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SINGER, JONATHAN PAUL · 2012 to 2016
$832k
Immune Mechanisms of Large-airway Lymphocytic BronchitisIK2CX001034 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI GREENLAND, JOHN · 2015 to 2019
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CSRD VA I01 CX002011CSRD VA IK2 CX001034NHLBI NIH HHS K23 HL111115NHLBI NIH HHS R01 HL134851
6 · The paper itself

Abstract

Post-operative delirium after lung transplantation is common. Its associations with health-related quality of life (HRQL), depression, and mortality remains unknown. In 236 lung transplant recipients, HRQL and depressive symptoms were assessed as part of a structured survey battery before and after transplantation. Surveys included the Geriatric Depressive Scale (GDS) and Short Form 12 (SF12). Delirium was assessed throughout the post-operative intensive care unit (ICU) stay with Confusion Assessment Method for ICU. Delirium and mortality data were extracted from electronic medical records. We examined associations between delirium and changes in depressive symptoms and HRQL using linear mixed effects models and association between delirium and mortality with Cox-proportional hazard models. Post-operative delirium occurred in 34 participants (14%). Delirium was associated with attenuated improvements in SF12-PCS (difference ₋4.0; 95%CI: -7.4, -0.7) but not SF12-MCS (difference 2.2; 95%CI: -0.7,5.7) or GDS (difference ₋0.4; 95%CI: -1.5,0.7). Thirty-two participants died during the study period. Delirium was associated with increased adjusted hazard risk of mortality (HR 17.9, 95%CI: 4.4,72.5). Delirium after lung transplantation identifies a group at increased risk for poorer HRQL and death within the first post-operative year. Further studies should investigate potential causal links between delirium, and poorer HRQL and mortality risk after lung transplantation.

Indexed as

DeliriumLung TransplantationAgedHumansIntensive Care UnitsPatient Reported Outcome MeasuresQuality of LifeCritical care medicinedeliriumdelirium outcomeslung transplantlung transplantation

Identifiers

PMID33682171
PMCPMC11098451

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.