ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2021
C-reactive protein in spinal surgery: more predictive than prehistoric.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- [Prospective comparative study of unilateral biportal endoscopic transforaminal lumbar interbody fusion and endoscopic transforaminal lumbar interbody fusion for treatment of single-segment degenerative lumbar spinal stenosis with lumbar spondylolisthesis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024Trial
- Development and internal validation of a nomogram for predicting postoperative bone nonunion in infectious spondylitis: a retrospective cohort study.Annals of medicine · 2026Article
- Risk Factors for Postoperative Complications in Different Fusion Surgical Approaches for Lumbar Degenerative Diseases.Journal of clinical medicine · 2026Article
- Postoperative C-Reactive Protein Trajectories in Spine Surgery - Influence of Vancomycin Powder: A Secondary Analysis of a Prospective Randomized Controlled Trial.Global spine journal · 2026Article
- Multiclass classification of infections after cervical spine surgery in the elderly: a machine learning approach based on preoperative and perioperative data.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Impact of dexamethasone on postoperative inflammatory markers and recovery outcomes in elderly patients undergoing open lumbar surgery.iScience · 2025Article
- Postoperative laboratory markers as predictors of early spinal surgical site infections: A retrospective cohort study.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2025Article
- Limited Diagnostic Utility of Postoperative C-Reactive Protein for Early Detection of Surgical Site Infections Following Posterior Scoliosis Correction Surgery.Journal of clinical medicine · 2025Article
- Predicting Surgical Site Infections in Spine Surgery: Association of Postoperative Lymphocyte Reduction.Diagnostics (Basel, Switzerland) · 2024Article
- Interleukin-6 as a critical inflammatory marker for early diagnosis of surgical site infection after spine surgery.Infection · 2024Article
- Prediction models for risk assessment of surgical site infection after spinal surgery: A systematic review.North American Spine Society journal · 2024Review
- Is an Elevated Preoperative CRP Level a Predictive Factor for Wound Healing Disorders following Lumbar Spine Surgery?Journal of personalized medicine · 2024Article
- Cerebrospinal Fluid Leakage Combined with Blood Biomarkers Predicts Poor Wound Healing After Posterior Lumbar Spinal Fusion: A Machine Learning Analysis.International journal of general medicine · 2024Article
- Does the use of epicutaneous vacuum-assisted closure after revision surgery on the spine reduce further wound revision surgery?International orthopaedics · 2023Article
- No more tears from surgical site infections in interventional pain management.The Korean journal of pain · 2023Review
- A nomogram for predicting post-operative wound complications after open reduction and internal fixation for calcaneal fractures.International wound journal · 2022Article
- Comparison of Perioperative Outcomes in Patients Undergoing Short-Level Lumbar Fusion Surgery After Implementing Enhanced Recovery After Surgery: A Propensity Score Matching Analysis Focusing on Young-Old and Old-Old.Clinical interventions in aging · 2022Article
- C-reactive protein to lymphocyte ratio as a new biomarker in predicting surgical site infection after posterior lumbar interbody fusion and instrumentation.Frontiers in surgery · 2022Article
- The Impact of Frailty on Perioperative Outcomes in Patients Receiving Short-Level Posterior Lumbar Interbody Fusion: A Stepwise Propensity Score Matching Analysis.Clinical interventions in aging · 2022Article
- Predicting the Exception-CRP and Primary Hip Arthroplasty.Journal of clinical medicine · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeIn spinal surgery, surgical site infections (SSI) after dorsal spondylodesis lead to severe short- and long-term complications. Despite various clinical and serological evidence, the detection of a postoperative SSI remains crucial. In this retrospective cohort study, we determined the prognostic value of C-reactive protein (CRP) kinetics after open reduction and dorsal spondylodesis in the development of a SSI.
methodsWe retrospectively analyzed 192 patients from 2016 to 2018 undergoing open reduction and dorsal spondylodesis with and without SSI for 20 days at a level-I trauma center and assessed their serological and clinical characteristics.
resultsOn day 7 and 8 after surgery, patients who developed a SSI displayed significantly higher CRP levels. A second peak after the initial maximum of CRP and a restricted failure to decline as well as a maximum CRP of more than 225 mg/l predict an infectious complication with a sensitivity of 92.9%, and a specificity of 78.2%. A binary logistic regression leads to 85.7% and 69.7%, respectively. A one-phase decay exponential regression can predict 75.6% of the variance after the initial peak of CRP.
conclusionOur study demonstrates a high value of postoperative CRP kinetics in SSI detection after dorsal spondylodesis. Moreover, we observed typical CRP levels with a specific course as indicative predictors that may facilitate an early SSI detection in clinical practice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.