ArticleThe Plant cell2021
Eleven biosynthetic genes explain the majority of natural variation in carotenoid levels in maize grain.
Article in The Plant cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Review
- Advancing provitamin A biofortification in sorghum: from allele mining and marker development to prebreeding and breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Short-term dietary deoxynivalenol exposure negatively affects performance, intestinal and reproductive functions in laying hens.Scientific reports · 2026Article
- Diversification of tobacco phytoene-synthase-encoding genes coordinates carotenoid flux, strigolactone biosynthesis, and cold responses.Frontiers in plant science · 2026Article
- Genetic Dissection of Carotenoid Variation by Integrating Quantitative Trait Loci Mapping and Candidate Region Association Study in Sweet Corn.Plants (Basel, Switzerland) · 2025Article
- Decades' progress and prospects on maize functional genomics and molecular breeding.Science China. Life sciences · 2025Review
- Preliminary Evaluation of lutein and zeaxanthin variability in DDGS from corn ethanol facilities.Biotechnology for biofuels and bioproducts · 2025Article
- Natural allelic variation of basic helix-loop-helix transcription factor 25 regulates carotenoid biosynthesis in sweet potato.Plant biotechnology journal · 2025Article
- Gene mapping and identification of candidate genes controlling carotenoid accumulation of yellow kernels in foxtail millet.BMC plant biology · 2025Article
- A detailed comparative in silico and functional analysis of ccd1 gene in maize gives new insights of its expression and functions.Molecular biology reports · 2025Article
- Biofortification: Future Challenges for a Newly Emerging Technology to Improve Nutrition Security Sustainably.Current developments in nutrition · 2024Article
- Grain yellowness is an effective predictor of carotenoid content in global sorghum populations.Scientific reports · 2024Article
- Molecular mechanisms underlying gene regulatory variation of maize metabolic traits.The Plant cell · 2024Article
- Investigating genomic prediction strategies for grain carotenoid traits in a tropical/subtropical maize panel.G3 (Bethesda, Md.) · 2024Article
- Multi-omics identification of a key glycosyl hydrolase gene FtGH1 involved in rutin hydrolysis in Tartary buckwheat (Fagopyrum tataricum).Plant biotechnology journal · 2024Article
- Leveraging prior biological knowledge improves prediction of tocochromanols in maize grain.The plant genome · 2023Article
- Genetic Variability in Carotenoid Contents in a Panel of Genebank Accessions of Temperate Maize from Southeast Europe.Plants (Basel, Switzerland) · 2023Article
- Unraveling transcriptomics of sorghum grain carotenoids: a step forward for biofortification.BMC genomics · 2023Article
- Characterization of grain carotenoids in global sorghum germplasm to guide genomics-assisted breeding strategies.BMC plant biology · 2023Article
- Biofortification to avoid malnutrition in humans in a changing climate: Enhancing micronutrient bioavailability in seed, tuber, and storage roots.Frontiers in plant science · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin A deficiency remains prevalent in parts of Asia, Latin America, and sub-Saharan Africa where maize (Zea mays) is a food staple. Extensive natural variation exists for carotenoids in maize grain. Here, to understand its genetic basis, we conducted a joint linkage and genome-wide association study of the US maize nested association mapping panel. Eleven of the 44 detected quantitative trait loci (QTL) were resolved to individual genes. Six of these were correlated expression and effect QTL (ceeQTL), showing strong correlations between RNA-seq expression abundances and QTL allelic effect estimates across six stages of grain development. These six ceeQTL also had the largest percentage of phenotypic variance explained, and in major part comprised the three to five loci capturing the bulk of genetic variation for each trait. Most of these ceeQTL had strongly correlated QTL allelic effect estimates across multiple traits. These findings provide an in-depth genome-level understanding of the genetic and molecular control of carotenoids in plants. In addition, these findings provide a roadmap to accelerate breeding for provitamin A and other priority carotenoid traits in maize grain that should be readily extendable to other cereals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.