ArticleBMJ neurology open2020
Association of cerebral blood flow with myelin content in cognitively unimpaired adults.
Article in BMJ neurology open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 36 citations in OpenAlex.
- The cerebral neurovascular coupling and glymphatic circulation dysfunction in children with attention deficit/hyperactivity disorder.BMC psychiatry · 2026Article
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- Arterial supply of the interpeduncular part of the human oculomotor nerve.Frontiers in neuroanatomy · 2026Article
- The vascular contribution to cognitive decline in ageing and dementia.Nature reviews. Neuroscience · 2025Review
- Phase contrast-derived cerebral blood flow is associated with neurodegeneration and cerebrovascular injury in older adults.Frontiers in neuroscience · 2025Article
- Change in transverse relaxation rates (RHuman brain mapping · 2025Article
- Regional cerebral blood flow reflects both neurodegeneration and microvascular integrity across the Alzheimer's continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- MRI Assessment of Cerebral White Matter Microvascular Hemodynamics Across the Adult Lifespan.Journal of magnetic resonance imaging : JMRI · 2024Article
- Harnessing myelin water fraction as an imaging biomarker of human cerebral aging, neurodegenerative diseases, and risk factors influencing myelination: A review.Journal of neurochemistry · 2024Review
- Evidence of association between higher cardiorespiratory fitness and higher cerebral myelination in aging.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Application study of DTI combined with ASL in the crossed cerebellar diaschisis after subacute cerebral hemorrhage.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Evidence of An Association Between Cerebral Blood Flow and Microstructural Integrity in Normative Aging Using a Holistic MRI Approach.Journal of magnetic resonance imaging : JMRI · 2023Article
- Lower myelin content is associated with more rapid cognitive decline among cognitively unimpaired individuals.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- The identification and cognitive correlation of perfusion patterns measured with arterial spin labeling MRI in Alzheimer's disease.Alzheimer's research & therapy · 2023Article
- The correlation between changes in gray matter microstructure and cerebral blood flow in Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- Metabolic syndrome and adiposity: Risk factors for decreased myelin in cognitively healthy adults.Cerebral circulation - cognition and behavior · 2023Article
- Association of Cerebral Blood Flow With Longitudinal Changes in Cerebral Microstructural Integrity in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.JAMA network open · 2022Article
- Differential associations between apolipoprotein E alleles and cerebral myelin content in normative aging.NeuroImage · 2022Article
- Assessment of cognitive impairment after acute cerebral infarction with T1 relaxation time measured by MP2RAGE sequence and cerebral hemodynamic by transcranial Doppler.Frontiers in neurology · 2022Article
- Investigation of the association between cerebral iron content and myelin content in normative aging using quantitative magnetic resonance neuroimaging.NeuroImage · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMyelin loss and cerebral blood flow (CBF) decline are central features of several neurodegenerative diseases. Myelin maintenance through oligodendrocyte metabolism is an energy-demanding process, so that myelin homeostasis is particularly sensitive to hypoxia, hypoperfusion or ischaemia. However, in spite of its central importance, little is known about the association between blood supply and myelin integrity.
objectiveTo assess associations between cortical and subcortical CBF, and subcortical myelin content, in critical brain white matter regions. MATERIALS AND
methodsMRI was performed on a cohort of 67 cognitively unimpaired adults. Using advanced MRI methodology, we measured whole-brain longitudinal and transverse relaxation rates (
resultsAll quantitative relaxometry metrics were positively associated with CBF in all brain regions evaluated. These associations between MWF or
conclusionsIn this first study examining the association between local blood supply and myelin integrity, we found that myelin content declines with CBF across a wide age range of cognitively normal subjects.
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