Evidence map›Paper›PMID 33681720›Full record

ArticleJournal of Alzheimer's disease reports2021

How Comorbidity Reflects on Cerebrospinal Fluid Biomarkers of Neurodegeneration in Aging.

Henri Zenuni, Piergiorgio Grillo, Giulia Maria Sancesario, Sergio Bernardini, Nicola Biagio Mercuri, Tommaso Schirinzi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Aging, frailty, and their effects on motor performance: evidence from kinematic analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Henri ZenuniDepartment of Systems Medicine, University of Roma Tor Vergata, Rome, Italy.
Piergiorgio GrilloDepartment of Systems Medicine, University of Roma Tor Vergata, Rome, Italy.
Giulia Maria SancesarioIRCCS Fondazione Santa Lucia, Rome, Italy.
Sergio BernardiniDepartment of Experimental Medicine, University of Roma Tor Vergata, Rome, Italy.
Nicola Biagio MercuriDepartment of Systems Medicine, University of Roma Tor Vergata, Rome, Italy.
Tommaso SchirinziDepartment of Systems Medicine, University of Roma Tor Vergata, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic comorbidity precipitates the risk for dementia. To comprehend the underlying mechanisms into a therapeutic perspective, we analyzed how comorbidity affects neurodegeneration-related cerebrospinal fluid (CSF) biomarkers of 55 cognitively intact subjects. The Charson Comorbidity Index (CCI) was correlated with CSF amyloid-β

Indexed as

Cerebrospinal fluid biomarkerscomorbidityneurodegenerationneuroprotectionoxidative stress

Identifiers

PMID33681720
PMCPMC7902985

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.