Evidence map›Paper›PMID 33681715›Full record

ArticleJournal of Alzheimer's disease reports2021

Sleep and Tau Pathology in Vietnam War Veterans with Preclinical and Prodromal Alzheimer's Disease.

Murray Andrews, Ryan Ross, Atul Malhotra, Sonia Ancoli-Israel, James B Brewer, Sarah J Banks, Alzheimer’s Disease Neuroimaging Initiative

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Axonal injury, sleep disturbances, and memory following traumatic brain injury.Annals of clinical and translational neurology · 2024
    Article
  5. Article
  6. Impaired sleep is associated with tau deposition onJournal of the neurological sciences · 2024
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Murray AndrewsDepartment of Neuroscience, University of California, San Diego, La Jolla, CA, USA.
Ryan RossDepartment of Neuroscience, University of California, San Diego, La Jolla, CA, USA.
Atul MalhotraDepartment of Health Sciences, University of California, San Diego, La Jolla, CA, USA.
Sonia Ancoli-IsraelDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
James B BrewerDepartment of Neuroscience, University of California, San Diego, La Jolla, CA, USA.
Sarah J BanksDepartment of Neuroscience, University of California, San Diego, La Jolla, CA, USA.
Alzheimer’s Disease Neuroimaging Initiative
University of California San Diego · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Steven Dyal Edland · 2019 to 2026
$34.9M
Sex-specific cognitive expression and risk in preclinical Alzheimer's diseaseR01AG066088 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BANKS, SARAH · 2019 to 2023
$3.9M
NIA NIH HHS P30 AG062429NIA NIH HHS R01 AG066088NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

backgroundThe increasing prevalence of Alzheimer's disease (AD) and lack of effective medications has led to a need to identify modifiable risk factors as targets for interventions.

objectiveIn this cross-sectional study, we sought to determine whether worse sleep quality is associated with increased pathological tau, and whether this relationship is affected by amyloid pathology.

methods66 male participants underwent Florbetapir (AV45) positron emission tomography (PET) and Flortaucipir (FTP) PET and completed the Pittsburgh Sleep Quality Index questionnaire (PSQI) as part of the Department of Defense Alzheimer's Disease Neuroimaging Initiative, a multicenter study collecting data from Vietnam War veterans, some of whom have a history of post-traumatic stress disorder, or non-penetrating traumatic brain injury. AV45 PET was used to determine the presence of significant amyloid pathology. We used regression models to determine the effects of amyloid pathology and PSQI on tau deposition in brain regions associated with Braak stages.

resultsAmong the 66 participants, 14 individuals were amyloid positive (21%) and 52 were amyloid negative (79%). In regions associated with Braak stages III-IV, there was a significant interaction of amyloid status on PSQI (β= 0.04,

conclusionOur study found that an AD profile of tau deposition was associated with an interaction between self-reported sleep quality and amyloid pathology such that worse self-reported sleep was related to higher tau in regions usually associated with AD progression, but only in individuals with high cerebral amyloid deposition.

Indexed as

Amyloidmild cognitive impairmentpositron emission tomographypreclinical ADsleeptau

Identifiers

PMID33681715
PMCPMC7903001
OpenAlexW3118537679

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.