ArticleEpilepsia open2021
Proposal to optimize evaluation and treatment of Febrile infection-related epilepsy syndrome (FIRES): A Report from FIRES workshop.
Article in Epilepsia open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Anti-Inflammatory and Antioxidant Strategies in Epilepsy: From Molecular Mechanisms to Threshold Management.International journal of molecular sciences · 2026Review
- Efficacy and safety of tocilizumab in the chronic phase of febrile infection-related epilepsy syndrome: a retrospective cohort study.World journal of pediatrics : WJP · 2026Article
- [How I treat pediatric febrile infection-related epilepsy syndrome].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- The Clinical Outcomes of Tocilizumab Usage in Cryptogenic Febrile Infection-Related Epilepsy Syndrome at Both Acute and Chronic Phase: A Retrospective Study.Journal of inflammation research · 2026Article
- Observational Study of Tocilizumab in Children With Febrile Infection-Related Epilepsy Syndrome.Annals of clinical and translational neurology · 2025Observational
- Adult-Onset Febrile Infection-Related Epilepsy Syndrome Treated with Short-Term Anakinra.Journal of epilepsy research · 2025Article
- Febrile Infection-Related Epilepsy Syndrome (FIRES) in children: a retrospective cohort study.European journal of pediatrics · 2025Article
- Case Report: Successful multimodal management of FIRES in a pediatric patient using anakinra, ketogenic diet, and induced hypothermia.Frontiers in pediatrics · 2025Article
- His brain is on FIRES.Journal of neurology · 2024Article
- Value of combining targeted emergency nursing with psychological nursing in children with febrile convulsions.World journal of clinical cases · 2024Article
- Article
- Molecularly targeted immunotherapy used to treat a novel overlap syndrome of pediatricAnnals of the Child Neurology Society · 2024Article
- Severe A(H1N1)pdm09 influenza acute encephalopathy outbreak in children in Tuscany, Italy, December 2023 to January 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024Article
- Case report: Febrile infection-related epilepsy syndrome in a 14-year-old girl with multiple organ failure and lethal outcome.Frontiers in neuroscience · 2024Article
- The Beneficial Outcome of Subsequent Treatment with Anakinra during the Chronic Phase of Febrile Infection-Related Epilepsy Syndrome (FIRES): A Case Report.Neurology international · 2023Article
- Cannabidiol in the acute phase of febrile infection-related epilepsy syndrome (FIRES).Epilepsia open · 2023Article
- Systemic inflammatory markers and EEG features of children with FIRES receiving anakinra.Annals of clinical and translational neurology · 2023Article
- AnFrontiers in neurology · 2023Article
- Long-term neuropsychological outcomes in children with febrile infection-related epilepsy syndrome (FIRES) treated with anakinra.Frontiers in neurology · 2023Article
- Febrile infection-related Epilepsy Syndrome (FIRES): a severe encephalopathy with status epilepticus. Literature review and presentation of two new cases.Italian journal of pediatrics · 2022Review
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21 authors.
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Abstract
Febrile infection-related epilepsy syndrome (FIRES) is a rare catastrophic epileptic encephalopathy that presents suddenly in otherwise normal children and young adults causing significant neurological disability, chronic epilepsy, and high rates of mortality. To suggest a therapy protocol to improve outcome of FIRES, workshops were held in conjunction with American Epilepsy Society annual meeting between 2017 and 2019. An international group of pediatric epileptologists, pediatric neurointensivists, rheumatologists and basic scientists with interest and expertise in FIRES convened to propose an algorithm for a standardized approach to the diagnosis and treatment of FIRES. The broad differential for refractory status epilepticus (RSE) should include FIRES, to allow empiric therapies to be started early in the clinical course. FIRES should be considered in all previously healthy patients older than two years of age who present with explosive onset of seizures rapidly progressing to RSE, following a febrile illness in the preceding two weeks. Once FIRES is suspected, early administrations of ketogenic diet and anakinra (the IL-1 receptor antagonist that blocks biologic activity of IL-1β) are recommended.
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