Evidence map›Paper›PMID 33681565›Full record

ArticleACS omega2021

Synthesis and Cytotoxic Activity of Novel Metal Complexes Derived from Methyl-3-(4-chlorophenyl)-3-hydroxy-2,2-dimethylpropanoate as Potential CDK8 Kinase Inhibitors.

Ahmed Aboelmagd, Samir M El Rayes, Mohamed S Gomaa, Walid Fathalla, Ibrahim A I Ali, Mohamed S Nafie, Faheem H Pottoo, Firdos Alam Khan, Mohamed M Ibrahim

Abstract read
In one paragraph

Article in ACS omega, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ahmed AboelmagdDepartment of Chemistry, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt.
Samir M El RayesDepartment of Chemistry, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt.
Mohamed S GomaaDepartment of Pharmaceutical, College of Clinical Pharmacy, ImamAbdulrahman Bin Faisal University, P. O. Box 1982, Dammam 31441, Kingdom of Saudi Arabia.
Walid FathallaDepartment of Physics and Math, Faculty of Engineering, Port-Said University, Port-Said 42526, Egypt.
Ibrahim A I AliDepartment of Chemistry, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt.
Mohamed S NafieDepartment of Chemistry, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt.
Faheem H PottooDepartment of Pharmacology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P. O. Box 1982, Dammam 31441, Kingdom of Saudi Arabia.
Firdos Alam KhanDepartment of Stem Cell Research, Institute of Research and Medical consultations (IRMC), Imam Abdulrahman Bin Faisal University, P. O. Box 1982, Dammam 31441, Saudi Arabia.
Mohamed M IbrahimDepartment of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several metal complexes of methyl-3-(4-chlorophenyl)-3-hydroxy-2,2-dimethylpropanoate derivatives were synthesized and tested for their anti-tumor activities. The ligands include 3-(4-chlorophenyl)-3-hydroxy-2,2-dimethylpropanoic acid (

Identifiers

PMID33681565
PMCPMC7931189

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.