ArticleJACC. Basic to translational science2021
SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis.
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Article in JACC. Basic to translational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers.
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127citing papers in PubMed
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Who cites it
127 citing papers in PubMed, 199 citations in OpenAlex.
- Heart-on-a-chip and vasculature-on-a-chip platforms as models of cardiovascular disease.Nature reviews. Cardiology · 2026Review
- Research progress on the association between viruses and cardiac diseases.Journal of virology · 2026Review
- Review
- "Bridging the clinical, molecular and genetic perspectives on myocarditis in post-COVID-19 era".International journal of cardiology. Cardiovascular risk and prevention · 2026Review
- Unbiased cleavage site prediction uncovers viral antagonism of host innate immunity by SARS-CoV-2 3C-like protease.JCI insight · 2026Article
- Molecular and Cellular Determinants of Human Iron Overload Cardiomyopathy.bioRxiv : the preprint server for biology · 2026Article
- Human Cardiac Organoids: Advances and Prospects from Construction to Preclinical Drug Evaluation.Cells · 2025Review
- Decoding long COVID-associated cardiovascular dysfunction: Mechanisms, models, and new approach methodologies.Journal of molecular and cellular cardiology · 2025Review
- SARS-CoV-2 spike protein-induced inflammation underlies proarrhythmia in COVID-19.Scientific reports · 2025Article
- Cardiac macrophage: Insights from murine models to translational potential for human studies.Journal of molecular and cellular cardiology · 2025Review
- COVID-19 and Myocarditis: Trends, Clinical Characteristics, and Future Directions.Journal of clinical medicine · 2025Review
- Bioengineering Approaches to In Vitro Modeling of Genetic and Acquired Cardiac Diseases.Current cardiology reports · 2025Review
- Clinical characteristics, diagnosis and short-term outcomes of COVID-19-associated acute myocarditis in China.ESC heart failure · 2025Article
- Epitranscriptomic Modulation of TET2 Inhibition Suppressed SARS-CoV-2 Infection and Blocked Viral Nucleocapsid Protein in Induced-Pluripotent-Stem-Cell-Derived Cardiomyocyte Screening Models.Biomaterials research · 2025Article
- The uses of right heart catheterization in cardio-pulmonary disease: State-of-the-art.American heart journal plus : cardiology research and practice · 2025Review
- SARS-CoV-2 ORF 3a-mediated currents are inhibited by antiarrhythmic drugs.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Article
- Exploring the impact of recent COVID-19 infection on perfusion and functional parameters derived from gated myocardial perfusion imaging in patients undergoing evaluation for coronary artery disease.Annals of nuclear medicine · 2024Article
- Infiltrating monocytes drive cardiac dysfunction in a cardiomyocyte-restricted mouse model of SARS-CoV-2 infection.Journal of virology · 2024Article
- Interactions of SARS-CoV-2 with Human Target Cells-A Metabolic View.International journal of molecular sciences · 2024Review
- SARS-CoV-2 variants divergently infect and damage cardiomyocytes in vitro and in vivo.Cell & bioscience · 2024Article
67 more citing papers are in PubMed but not listed here.
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Authors and funding
29 authors at 9 institutions in 2 countries.
Adam L BaileyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Oleksandr DmytrenkoCardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Lina GreenbergDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA.
Andrea L BredemeyerCardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Pan MaCardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Jing LiuCardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Vinay PennaCardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Emma S WinklerDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Sanja SvibenWashington University Center for Cellular Imaging, Washington University School of Medicine, St. Louis, Missouri, USA.
Erin BrooksDepartment of Pathology & Laboratory Medicine, University of Wisconsin Hospital and Clinics, Madison, Wisconsin, USA.
Ajith P NairDepartment of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Kent A HeckDepartment of Pathology, Baylor College of Medicine, Houston, Texas, USA.
Aniket S RaliDepartment of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Leo SimpsonDepartment of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Mehrdad SaririanValleywise Health/Creighton University, Phoenix, Arizona, USA.
Dan HobohmValleywise Health/Creighton University, Phoenix, Arizona, USA.
W Tom StumpDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA.
James A FitzpatrickWashington University Center for Cellular Imaging, Washington University School of Medicine, St. Louis, Missouri, USA.
Xuping XieDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.
Xianwen ZhangDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.
Pei-Yong ShiDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.
J Travis HinsonDepartments of Cardiology, Genetics and Genome Sciences, UConn Health, Farmington, Connecticut, USA.
Weng-Tein GiDepartment of Internal Medicine III, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.
Constanze SchmidtDepartment of Internal Medicine III, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.
Florian LeuschnerDepartment of Internal Medicine III, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.
Chieh-Yu LinDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Michael S DiamondDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Michael J GreenbergDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, USA.
Kory J LavineDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Washington University in St. Louis · USBaylor College of Medicine · USThe University of Texas Medical Branch at Galveston · USCreighton University · USHeidelberg University · DEJackson Laboratory · USUniversity Hospital Heidelberg · DEUW Health University Hospital · USVanderbilt University · US
Funding
NATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8MTRAINING PROGRAM IN IMMUNOLOGY AND IMMUNOGENETICST32AI007163 · NIAID · WASHINGTON UNIVERSITY · PI Kenneth M Murphy, Kodi S Ravichandran · 1985 to 2026
$14.8MHuman antibody-based countermeasures against the Wuhan Coronavirus SARS-CoV-2R01AI157155 · NIAID · WASHINGTON UNIVERSITY · PI BARIC, RALPH S, CROWE, JAMES E · 2020 to 2024
$6.0MRegulation of cardiac power output in health and diseaseR01HL141086 · NHLBI · WASHINGTON UNIVERSITY · PI GREENBERG, MICHAEL J · 2018 to 2022
$2.7MMACROPHAGE HETEROGENEITY IN HEART FAILURE PROGRESSION AND CARDIAC RECOVERYR01HL138466 · NHLBI · WASHINGTON UNIVERSITY · PI LAVINE, KORY J. · 2017 to 2021
$1.9MMACROPHAGE ONTOGENY SHIFTS IN ISCHEMIC HEART DISEASER01HL139714 · NHLBI · WASHINGTON UNIVERSITY · PI LAVINE, KORY J. · 2018 to 2021
$1.5MRole of ontogeny and niche on human macrophage developmentR21AI148877 · NIAID · WASHINGTON UNIVERSITY · PI LAVINE, KORY J., STURGEON, CHRISTOPHER MICHAEL · 2020 to 2021
$433kRegulation of Antiviral Responses in Plasmacytoid Dendritic Cells to Chikungunya Virus by the Gut MicrobiotaF30AI152327 · NIAID · WASHINGTON UNIVERSITY · PI WINKLER, EMMA SUENING · 2021 to 2022
$84kNHLBI NIH HHS R01 HL138466NHLBI NIH HHS R01 HL139714NHLBI NIH HHS R01 HL141086NIAID NIH HHS F30 AI152327NIAID NIH HHS R01 AI157155NIAID NIH HHS R21 AI148877NIAID NIH HHS T32 AI007163NIGMS NIH HHS T32 GM007200
Abstract
There is ongoing debate as to whether cardiac complications of coronavirus disease-2019 (COVID-19) result from myocardial viral infection or are secondary to systemic inflammation and/or thrombosis. We provide evidence that cardiomyocytes are infected in patients with COVID-19 myocarditis and are susceptible to severe acute respiratory syndrome coronavirus 2. We establish an engineered heart tissue model of COVID-19 myocardial pathology, define mechanisms of viral pathogenesis, and demonstrate that cardiomyocyte severe acute respiratory syndrome coronavirus 2 infection results in contractile deficits, cytokine production, sarcomere disassembly, and cell death. These findings implicate direct infection of cardiomyocytes in the pathogenesis of COVID-19 myocardial pathology and provides a model system to study this emerging disease.
Indexed as
ACE2, angiotensin converting enzyme 2cardiomyocytecoronavirus disease 2019COVID-19, coronavirus disease-2019EHT, engineered heart tissuesengineered heart tissuehPSC, human pluripotent stem cell(s)LV, left ventriclemyocarditisSARS-CoV-2, severe acute respiratory syndrome-coronavirus-2severe acute respiratory syndrome coronavirus 2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.