Evidence map›Paper›PMID 33681462›Full record

ArticleTomography (Ann Arbor, Mich.)2021

A System-Agnostic, Adaptable and Extensible Animal Support Cradle System for Cardio-Respiratory-Synchronised, and Other, Multi-Modal Imaging of Small Animals.

Veerle Kersemans, Stuart Gilchrist, Philip Danny Allen, Sheena Wallington, Paul Kinchesh, John Prentice, Martin Tweedie, Jamie H Warner, Sean C Smart

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tomography (Ann Arbor, Mich.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Veerle KersemansPreclinical Imaging Scientific Research Facility, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK.
Stuart GilchristPreclinical Imaging Scientific Research Facility, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK.
Philip Danny AllenPreclinical Imaging Scientific Research Facility, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK.
Sheena WallingtonPreclinical Imaging Scientific Research Facility, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK.
Paul KincheshPreclinical Imaging Scientific Research Facility, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK.
John PrenticePreclinical Imaging Scientific Research Facility, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK.
Martin TweedieDepartment of Materials, Quantum Information Processing Interdisciplinary Research Collaboration, University of Oxford, Parks Road, Oxford OX1 3PH, UK.
Jamie H WarnerDepartment of Materials, Quantum Information Processing Interdisciplinary Research Collaboration, University of Oxford, Parks Road, Oxford OX1 3PH, UK.
Sean C SmartPreclinical Imaging Scientific Research Facility, Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Standardisation of animal handling procedures for a wide range of preclinical imaging scanners will improve imaging performance and reproducibility of scientific data. Whilst there has been significant effort in defining how well scanners should operate and how in vivo experimentation should be practised, there is little detail on how to achieve optimal scanner performance with best practices in animal welfare. Here, we describe a system-agnostic, adaptable and extensible animal support cradle system for cardio-respiratory-synchronised, and other, multi-modal imaging of small animals. The animal support cradle can be adapted on a per application basis and features integrated tubing for anaesthetic and tracer delivery, an electrically driven rectal temperature maintenance system and respiratory and cardiac monitoring. Through a combination of careful material and device selection, we have described an approach that allows animals to be transferred whilst under general anaesthesia between any of the tomographic scanners we currently or have previously operated. The set-up is minimally invasive, cheap and easy to implement and for multi-modal, multi-vendor imaging of small animals.

Indexed as

AnestheticsHeartAnimalsMultimodal ImagingReproducibility of ResultsAnestheticshandling apparatusimaging-compatiblemulti-modal imagingmulti-vendoroptimisation

Identifiers

PMID33681462
PMCPMC7934707

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.