ArticleAlzheimer's & dementia (New York, N. Y.)2021
Transcranial ultrasound pulse stimulation reduces cortical atrophy in Alzheimer's patients: A follow-up study.
Article in Alzheimer's & dementia (New York, N. Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06178952 (Transcranial Pulse Stimulation), which is not on this map. Cited by 42 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transcranial Pulse Stimulation (TPS) in Post-COVID-19
Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Ultrasound-induced blood-brain barrier opening in Alzheimer's disease: a systematic review of clinical studies.Aging clinical and experimental research · 2026Pooled it
- Transcranial ultrasound stimulation parameters for neurological diseases: a systematic review.Frontiers in neurology · 2025Pooled it
- Transcranial ultrasound stimulation in neuromodulation: a bibliometric analysis from 2004 to 2024.Frontiers in neuroscience · 2025Pooled it
- Effects of Transcranial Pulse Stimulation of the Primary Motor Cortex on Motor Performance in Healthy Adults: A Randomized Crossover Pilot Study.CNS neuroscience & therapeutics · 2025Trial
- Ultrasound Neuromodulation With Transcranial Pulse Stimulation in Alzheimer Disease: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Effects of Transcranial Pulse Stimulation (TPS) on Adults with Symptoms of Depression-A Pilot Randomized Controlled Trial.International journal of environmental research and public health · 2023Trial
- Transcranial Focused Ultrasound Stimulation for Alzheimer's Disease-A Scoping Review.Brain sciences · 2026Review
- Article
- Noninvasive Brain Stimulation Techniques and Their Efficacy in Treating Cognition and Memory in Mild Cognitive Impairment and Alzheimer's Disease-A Systematic Review.Brain sciences · 2026Review
- Multimodal preclinical study of long-term effects of prenatal ultrasound on the mouse central nervous system.Scientific reports · 2026Article
- Effects of noninvasive brain stimulation on motor functions in animal models of ischemia and trauma in the central nervous system.Neural regeneration research · 2026Article
- Translational prospectives for deep brain stimulation and low-intensity focused ultrasound neuromodulation: IFCN Handbook chapter.Clinical neurophysiology practice · 2026Review
- Ultrasound neuromodulation in brain disorders: from mechanotransduction mechanisms to clinical translation.Frontiers in neuroscience · 2026Review
- Home-administered unfocused transcranial ultrasound in subjective cognitive decline and dementia: an open-label, uncontrolled feasibility pilot study.Frontiers in aging neuroscience · 2026Article
- Neuromodulatory Effects of Transcranial Pulse Stimulation (TPS) in Neurological and Psychiatric Disorders-A Systematic Review and Meta-Analysis.Neurology international · 2025Review
- A novel application of transcranial pulse stimulation in rehabilitation: pain management in refractory knee osteoarthritis - a case series.Journal of rehabilitation medicine · 2025Article
- Transcranial Pulse Stimulation in Alzheimer's: Long-Term Feasibility and a Multifocal Treatment Approach.Brain sciences · 2025Article
- Study Protocol: Investigating the Effects of Transcranial Pulse Stimulation in Parkinson's Disease.Bioengineering (Basel, Switzerland) · 2025Article
- Article
- A Comprehensive Review of Low-Intensity Focused Ultrasound Parameters and Applications in Neurologic and Psychiatric Disorders.Neuromodulation : journal of the International Neuromodulation Society · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionUltrasound for the brain is a revolutionary therapeutic concept. The first clinical data indicate that 2-4 weeks of therapy with transcranial pulse stimulation (TPS) improve functional networks and cognitive performance of Alzheimer's disease (AD) patients for up to 3 months. No data currently exist on possible benefits concerning brain morphology, namely the cortical atrophy characteristic of AD.
methodsWe performed a pre-/post-therapy analysis of cortical thickness in a group of N = 17 AD patients.
resultsWe found a significant correlation between neuropsychological improvement and cortical thickness increase in AD-critical brain areas. DISCUSSION: AD patients who benefit from TPS appear to manifest reduced cortical atrophy within the default mode network in particular, whose memory-related subsystems are believed to be disrupted in AD. TPS may therefore hold promise as a new add-on therapy for AD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.