Evidence map›Paper›PMID 33681435›Full record

ArticleData in brief2021

Transcriptomic data of Clozapine-treated Ngn2-induced Human Excitatory Neurons.

Anh-Thu N Lam, Xi Peng, Debamitra Das, Joel S Bader, Dimitrios Avramopoulos

Open access · goldAbstract read
In one paragraph

Article in Data in brief, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Anh-Thu N LamDepartment of Genetic Medicine, Johns Hopkins University School of Medicine, United States of America.
Xi PengDepartment of Biomedical Engineering, Whiting School of Engineering and School of Medicine, Johns Hopkins University, United States of America.
Debamitra DasDepartment of Genetic Medicine, Johns Hopkins University School of Medicine, United States of America.
Joel S BaderDepartment of Genetic Medicine, Johns Hopkins University School of Medicine, United States of America.
Dimitrios AvramopoulosDepartment of Genetic Medicine, Johns Hopkins University School of Medicine, United States of America.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

Project 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2020
$19.9M
SZ-associated loci: Functional consequences and treatment opportunitiesR01MH113215 · NIMH · JOHNS HOPKINS UNIVERSITY · PI AVRAMOPOULOS, DIMITRIOS · 2018 to 2021
$3.8M
Understanding GWAS signals: functional variants or functional haplotypes?R21MH122936 · NIMH · JOHNS HOPKINS UNIVERSITY · PI AVRAMOPOULOS, DIMITRIOS · 2020 to 2020
$450k
NIMH NIH HHS P50 MH094268NIMH NIH HHS R01 MH113215NIMH NIH HHS R21 MH122936
6 · The paper itself

Abstract

We generated human excitatory neurons using a protocol for rapid 21-day induction using neurogenin-2 overexpression (Zhang et al., 2013) in a publicly available control iPSC line

Indexed as

AntipsychoticsCholesterol metabolismClozapineGene expressionSchizophreniaTranscriptome

Identifiers

PMID33681435
PMCPMC7910509
OpenAlexW3131153584

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.