Evidence map›Paper›PMID 33681430›Full record

ArticleBone reports2021

Low magnetic field promotes recombinant human BMP-2-induced bone formation and influences orientation of trabeculae and bone marrow-derived stromal cells.

Rintaro Okada, Kai Yamato, Minoru Kawakami, Joe Kodama, Junichi Kushioka, Daisuke Tateiwa, Yuichiro Ukon, Bal Zeynep, Takuya Ishimoto, Takayoshi Nakano and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Rintaro OkadaDepartment of Orthopedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Kai YamatoDepartment of Research Institute, PIP Corporation, Ibaraki, Osaka, Japan.
Minoru KawakamiDepartment of Research Institute, PIP Corporation, Ibaraki, Osaka, Japan.
Joe KodamaDepartment of Orthopedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Junichi KushiokaDepartment of Orthopedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Daisuke TateiwaDepartment of Orthopedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Yuichiro UkonDepartment of Orthopedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Bal ZeynepDepartment of Orthopedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Takuya IshimotoDivision of Materials and Manufacturing Science, Osaka University Graduate School of Engineering, Suita, Osaka, Japan.
Takayoshi NakanoDivision of Materials and Manufacturing Science, Osaka University Graduate School of Engineering, Suita, Osaka, Japan.
Hideki YoshikawaDepartment of Orthopedic Surgery, Toyonaka Municipal Hospital, Toyonaka, Osaka, Japan.
Takashi KaitoDepartment of Orthopedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Osaka University · JPToyonaka Municipal Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effects of high magnetic fields [MFs, ≥ 1 T (T)] on osteoblastic differentiation and the orientation of cells or matrix proteins have been reported. However, the effect of low MFs (< 1 T) on the orientation of bone formation is not well known. This study was performed to verify the effects of low MFs on osteoblastic differentiation, bone formation, and orientation of both cells and newly formed bone. An apparatus was prepared with two magnets (190 mT) aligned in parallel to generate a parallel MF.

Indexed as

ALP, alkaline phosphataseBMD, bone mineral densityBMDCs, bone marrow derived stromal cellsBone marrow-derived stromal cellsBV, bone volumeCOL1a1, collagen type1 a1FFT, fast Fourier transformGFP, green fluorescent proteinMagnetic fieldMechanical strengthMF, magnetic fieldmicro-CT, micro-computed tomographyOCN, osteocalcinOPN, osteopontinOrientation intensityOsteoblastic differentiationOSX, osterixPBS, phosphate-buffered salinePEMF, pulsed electromagnetic fieldrhBMP, recombinant human bone morphogenetic proteinROI, region of interestRT-PCR, reverse transcription polymerase chain reactionRUNX2, runt-related transcription factor 2μXRD, microbeam X-ray diffractometer

Identifiers

PMID33681430
PMCPMC7910497
OpenAlexW3129248353

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.