Evidence map›Paper›PMID 33681250›Full record

ArticleFrontiers in medicine2021

Professional-Grade TCA-Lactic Acid Chemical Peel: Elucidating Mode of Action to Treat Photoaging and Hyperpigmentation.

Vinay Bhardwaj, Krati Sharma, Srdjan Maksimovic, Aixing Fan, Alison Adams-Woodford, Junhong Mao

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. A Tensioned Human Skin Explant Model Used for Preliminary Assessment of Chemexfoliant-Stimulated Bioeffects.JID innovations : skin science from molecules to population health · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Vinay BhardwajDepartment of Global Personal Care and Skin Health R&D, Colgate-Palmolive Company, Piscataway, NJ, United States.
Krati SharmaIndependent Researcher, Philadelphia, PA, United States.
Srdjan MaksimovicDepartment of Global Personal Care and Skin Health R&D, Colgate-Palmolive Company, Piscataway, NJ, United States.
Aixing FanDepartment of Global Personal Care and Skin Health R&D, Colgate-Palmolive Company, Piscataway, NJ, United States.
Alison Adams-WoodfordPhysicians Care Alliance (PCA) SKIN, Scottsdale, AZ, United States.
Junhong MaoDepartment of Global Personal Care and Skin Health R&D, Colgate-Palmolive Company, Piscataway, NJ, United States.
Colgate-Palmolive (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemical peeling is usually performed by dermatologists, plastic surgeons, and aestheticians for the treatment of photo-aged skin, dyspigmented skin, skin prone to acne eruption, and pre-cancerous skin lesions, etc. In this research paper, we report our investigative findings to understand the mode of action of a commercial professional chemical peel to treat hyperpigmented and photoaged skin. In the

Indexed as

anti-pigmentationchemical peelingcollagenmelaninmolecular dockingphoto-aging

Identifiers

PMID33681250
PMCPMC7928281
OpenAlexW3130640361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.