Evidence map›Paper›PMID 33681225›Full record

ArticleFrontiers in cell and developmental biology2021

Tumor-Associated Microbiota in Esophageal Squamous Cell Carcinoma.

Weixiong Yang, Chang-Han Chen, Minghan Jia, Xiangbin Xing, Lu Gao, Hsin-Ting Tsai, Zhanfei Zhang, Zhenguo Liu, Bo Zeng, Sai-Ching Jim Yeung and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 71 citations in OpenAlex.

  1. IntratumorGut microbes · 2026
    Article
  2. Article
  3. Esophageal cancer: from pathogenesis to precision therapies.Signal transduction and targeted therapy · 2026
    Review
  4. Microbiota in cancer: current understandings and future perspectives.Signal transduction and targeted therapy · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Weixiong YangDepartment of Thoracic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Chang-Han ChenDepartment of Applied Chemistry, and Graduate Institute of Biomedicine and Biomedical Technology, National Chi Nan University, Nantou County, Taiwan.
Minghan JiaDepartment of Breast Cancer, Cancer Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Xiangbin XingDepartment of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Lu GaoBGI Genomics, BGI-Shenzhen, Shenzhen, China.
Hsin-Ting TsaiDepartment of Applied Chemistry, and Graduate Institute of Biomedicine and Biomedical Technology, National Chi Nan University, Nantou County, Taiwan.
Zhanfei ZhangDepartment of Thoracic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zhenguo LiuDepartment of Thoracic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Bo ZengDepartment of Thoracic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Sai-Ching Jim YeungDepartment of Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Mong-Hong LeeGuangdong Research Institute of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Chao ChengDepartment of Thoracic Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
The First Affiliated Hospital, Sun Yat-sen University · CNNational Chi Nan University · TWBGI GenomicsGuangdong Academy of Medical Sciences · CNSixth Affiliated Hospital of Sun Yat-sen University · CNSun Yat-sen University · CNThe University of Texas MD Anderson Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Important evidence indicates the microbiota plays a key role in esophageal squamous cell carcinoma (ESCC). The esophageal microbiota was prospectively investigated in 18 patients with ESCC and 11 patients with physiological normal (PN) esophagus by 16S rRNA gene profiling, using next-generation sequencing. The microbiota composition in tumor tissues of ESCC patients were significantly different from that of patients with PN tissues. The ESCC microbiota was characterized by reduced microbial diversity, by decreased abundance of

Indexed as

carcinogenesisesophageal squamous cell carcinomaFusobacteriamicrobial dysbiosis indexmicrobiota

Identifiers

PMID33681225
PMCPMC7930383
OpenAlexW3118129090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.