Evidence map›Paper›PMID 33681212›Full record

ArticleFrontiers in cell and developmental biology2021

Embryonic Expression of Nras

Xiaona You, Myung-Jeom Ryu, Eunjin Cho, Yanzhi Sang, Alisa Damnernsawad, Yun Zhou, Yangang Liu, Jing Zhang, Youngsook Lee

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Science advances · 2026
    Article
  2. Review
  3. The role of CoQ10 in embryonic development.Journal of assisted reproduction and genetics · 2024
    Review
  4. Expanding the Genetic Code ofACS chemical biology · 2024
    Article
  5. International journal of molecular sciences · 2021
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xiaona YouMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, United States.
Myung-Jeom RyuMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, United States.
Eunjin ChoDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, United States.
Yanzhi SangMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, United States.
Alisa DamnernsawadMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, United States.
Yun ZhouMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, United States.
Yangang LiuMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, United States.
Jing ZhangMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, United States.
Youngsook LeeDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, United States.
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
The role of TCOF1 in germline predisposition to and in leukemic transformation of chronic myelomonocytic leukemiaR01CA152108 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Jing Zhang · 2011 to 2026
$5.4M
Dose-dependent Activation of the MEK/ERK Pathway in HematopoiesisR01HL113066 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI ZHANG, JING · 2013 to 2016
$1.5M
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA152108NHLBI NIH HHS R01 HL113066
6 · The paper itself

Abstract

Ras proteins control a complex intracellular signaling network. Gain-of-function mutations in

Indexed as

congenital heart defectsembryonic developmentfetal liver hematopoiesisheart developmentNoonan syndromeNras mutationRASopathy

Identifiers

PMID33681212
PMCPMC7928391
OpenAlexW3127222371

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.