ArticleJournal of clinical orthopaedics and trauma2021
Gene Xpert/MTB RIF assay for spinal tuberculosis- sensitivity, specificity and clinical utility.
Article in Journal of clinical orthopaedics and trauma, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Diagnostic accuracy of GeneXpert in the diagnosis of spinal tuberculosis: A systematic review and meta-analysis.Narra J · 2024Pooled it
- A systematic review and meta-analysis of circulating serum and plasma microRNAs in TB diagnosis.BMC infectious diseases · 2024Pooled it
- Comparative analysis of pathogen detection methods in spinal infections: a retrospective study of 287 cases.BMC infectious diseases · 2026Article
- Comparison of characteristics of drug-resistantJournal of family medicine and primary care · 2026Article
- A Rare Case of Multilevel Pott's Disease With Coexistent Pulmonary Cavitary Tuberculosis and Neurogenic Bladder.Cureus · 2025Article
- Clinical and epidemiological analysis of 893 patients with spinal tuberculosis: an 11-Year investigation of a general hospital in East China.BMC musculoskeletal disorders · 2025Article
- Computed Tomography Guided Biopsy and Gene X-pert MTB/Rif Ultra can be Deceptive in Spondylodiscitis - A Rare Case Report of Hodgkin's Lymphoma Mimicking Spondylodiscitis.Journal of orthopaedic case reports · 2025Article
- Molecular mechanisms related to bone damage in spinal tuberculosis revealed by 4D-label-free proteomics analysis.Frontiers in cellular and infection microbiology · 2025Article
- Evaluation of molecular and bacteriological detection methods performed on the formalin-fixed paraffin-embedded biopsy samples collected from endometrial and lymph node tuberculosis suspected patients.BMC infectious diseases · 2024Article
- Article
- Rifampicin Resistance Pattern of Mycobacterium tuberculosis Infection in Tertiary Care Hospital Settings.Cureus · 2024Article
- Utility of clinicoradiological, microbiological, histopathological, and molecular methods in the diagnosis of spinal tuberculosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Article
- Review
- Long-segment Continuous Multi-level Spinal Tuberculosis without Bony Destruction Leading to Rapid Paraplegia in an Immunocompetent Patient.Journal of orthopaedic case reports · 2023Article
- Comparative analysis of five etiological detecting techniques for the positive rates in the diagnosis of tuberculous granuloma.Journal of clinical tuberculosis and other mycobacterial diseases · 2023Article
- Clinical Value of Metagenomic Next-Generation Sequencing Using Spinal Tissue in the Rapid Diagnosis of Spinal Tuberculosis.Infection and drug resistance · 2023Article
- The value of histopathology combined with CapitalBioFrontiers in medicine · 2023Article
- Improved accuracy of etiological diagnosis of spinal infection by metagenomic next-generation sequencing.Frontiers in cellular and infection microbiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundXpert MTB/RIF assay is a rapid automated molecular test with excellent reported sensitivity, specificity for diagnosis of pulmonary and extrapulmonary Mycobacterium
methodsA retrospective review of medical records was performed for 136 patients that underwent spinal biopsy for suspected spondylodiscitis. Reports for acid fast bacilli (AFB) smear, gram stain, pyogenic culture, MTB culture, histopathology, Xpert MTB/RIF assay, and drug sensitivity testing were reviewed. '
resultsA total of 125 patients were considered for final analysis, 86 patients met the criteria for '
conclusionsGene Xpert MTB/RIF showed excellent specificity and was accurate in the identification of drug resistance. The sensitivity was 65% and sampling techniques using pus samples rather than tissue samples could be a possible reason for lower sensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.