ArticleBiomedical optics express2021
Malignant and benign thyroid nodule differentiation through the analysis of blood plasma with terahertz spectroscopy.
Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 34 citations in OpenAlex.
- Chemical-enhanced thyroid cell detection using photonic crystal biosensors with phase-change materials.RSC advances · 2026Article
- Review
- Measurement of tissue optical properties in a wide spectral range: a review [Invited].Biomedical optics express · 2023Review
- Dielectric property measurement of human sweat using attenuated total reflection terahertz time domain spectroscopy.Biomedical optics express · 2022Article
- Moisture adsorption by decellularized bovine pericardium collagen matrices studied by terahertz pulsed spectroscopy and solid immersion microscopy.Biomedical optics express · 2021Article
- Cellular effects of terahertz waves.Journal of biomedical optics · 2021Review
- Terahertz dielectric spectroscopy and solid immersion microscopy ofBiomedical optics express · 2021Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The liquid and lyophilized blood plasma of patients with benign or malignant thyroid nodules and healthy individuals were studied by terahertz (THz) time-domain spectroscopy and machine learning. The blood plasma samples from malignant nodule patients were shown to have higher absorption. The glucose concentration and miRNA-146b level were correlated with the sample's absorption at 1 THz. A two-stage ensemble algorithm was proposed for the THz spectra analysis. The first stage was based on the Support Vector Machine with a linear kernel to separate healthy and thyroid nodule participants. The second stage included additional data preprocessing by Ornstein-Uhlenbeck kernel Principal Component Analysis to separate benign and malignant thyroid nodule participants. Thus, the distinction of malignant and benign thyroid nodule patients through their lyophilized blood plasma analysis by terahertz time-domain spectroscopy and machine learning was demonstrated.
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Registered trials
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