ArticleCaspian journal of internal medicine2020
Pre and post chemotherapy evaluation of breast cancer patients: Biochemical approach of serum selenium and antioxidant enzymes.
Article in Caspian journal of internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 4 citations in OpenAlex.
- Interleukin-38 serum levels in breast cancer: A comparative analysis of women under 40 and over 50.Caspian journal of internal medicine · 2026Article
- Nanoparticle-Based Antioxidants in Stress Signaling and Programmed Cell Death in Breast Cancer Treatment.Molecules (Basel, Switzerland) · 2023Review
- Therapeutic Benefits of Selenium in Hematological Malignancies.International journal of molecular sciences · 2022Review
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
backgroundChemotherapy for treatment of breast cancer uses some drugs to target and destroy the cancer cells. However, most of antineoplastic treatments are non-specific and the innate cells will be damaged. In this study, the effect of adriamycin/cytoxan (AC) chemotherapy on the status of antioxidant enzymes and Se levels in breast cancer patients was evaluated.
methodsA prospective study, includes 50 breast cancer patients treated with AC chemotherapy (adriamycin 60 mg/m
resultsAfter 3 courses of chemotherapy, a significant decrease was observed in antioxidant enzymes and also Se (p<0.001). These studied indices were not significant in different age groups (≤48, >48) and stages of disease (early, advanced).
conclusionOur findings show that the AC chemotherapy in the breast cancer patients result in drastic changes in oxidant/antioxidant system of the body, especially reduction of Se levels and antioxidant enzymes activities. However, it seems that these changes are not necessarily dependent on the age and disease stage.
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