ArticleCaspian journal of internal medicine2020
Role of EGFR gene polymorphisms in oral squamous cell carcinoma patients of Southeast Iran: A case-control study.
Article in Caspian journal of internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 14 citations in OpenAlex.
- Structural pharmacogenomics of drug-associated SNPs in oral squamous cell carcinoma.Frontiers in genetics · 2026Article
- High Prevalence of EGFR R479K (rs2227983) Polymorphism in Indian Head and Neck Cancer Patients: Association with Unfavourable Clinical Outcome.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Unravelling molecular mechanism of oral squamous cell carcinoma and genetic landscape: an insight into disease complexity, available therapies, and future considerations.Frontiers in immunology · 2025Review
- Association of lncRNA ANRIL rs10757278 A>G Variant, Tumor Size, Grading, Tumor Site, and Tumor Stage in Oral Squamous Cell Carcinoma Patients.Reports of biochemistry & molecular biology · 2024Article
- Comprehensive Analysis of the Prognostic Marker and Immune Infiltrates of LDLR-Related Proteins Family Members in Breast Cancer.Iranian journal of pathology · 2024Article
- Epigenetic Regulation in Oral Squamous Cell Carcinoma Microenvironment: A Comprehensive Review.Cancers · 2023Review
- Two independent variants of epidermal growth factor receptor associated with risk of glioma in a Korean population.Scientific reports · 2022Article
- Synonymous Variants: Necessary Nuance in Our Understanding of Cancer Drivers and Treatment Outcomes.Journal of the National Cancer Institute · 2022Review
- A micro-peptide encoded by HOXB-AS3 promotes the proliferation and viability of oral squamous cell carcinoma cell lines by directly binding with IGF2BP2 to stabilize c-Myc.Oncology letters · 2021Article
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3 authors at 1 institution in 1 country.
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Abstract
backgroundThe decisive etiology of oral squamous cell carcinoma (OSCC) is still ambiguous, but we recognize the contribution of genetic aberration and environmental agents due to OSCC initiation. In the current study, we elucidate the potential impact of EGFR gene polymorphisms on the risk of OSCC in Southeast Iran.
methodsForty-eight OSCC patients along with 100 healthy volunteers were included. Three polymorphisms of the EGFR gene (rs2227983, rs2293347 and rs2227984) were genotype by Tetra-ARMS PCR. Data were analyzed with a chi-square test, and p<0.05 was considered significant.
resultsIn rs2227983, the frequency of AG and GG genotypes were 62.5%, 37.5% in cases and 42%, 57% in the control group (P=0.02, OR=2.3) and also A allele frequency was 31.3% in the case and 22% in control (P=0.08, OR=0.62). AG + AA genotype frequency was 62.5% and 43% in case and control, respectively (p=0.03, OR=2.2). In rs2227984 and rs2293347, no statistical differences showed in the distribution of genotypes between the case and control group. Also the majority of the OSCC belonged to grade I (43.8%).
conclusionThe present investigation indicated that rs2227983 polymorphism might contribute to OSCC susceptibility in Iran's southeast population. Although, with the inconsistent interpretation mentioned due to the various geographical residencies and populations, more studies of significant populations are suggested to validate our findings.
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