Evidence map›Paper›PMID 33680355›Full record

ArticleComputational and structural biotechnology journal2021

Binding of non-canonical peptidoglycan controls

Akbar Espaillat, Cesar Carrasco-López, Noelia Bernardo-García, Alzoray Rojas-Altuve, Javier Klett, Antonio Morreale, Juan A Hermoso, Felipe Cava

Open access · goldAbstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. A prototrophic suppressor of aJournal of bacteriology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Akbar EspaillatDepartment of Molecular Biology and Laboratory for Molecular Infection Medicine Sweden, Umeå Centre for Microbial Research, Umeå University, Umeå, Sweden.
Cesar Carrasco-LópezDepartment of Crystallography & Structural Biology, Institute of Physical-Chemistry "Rocasolano", CSIC, Madrid 28006, Spain.
Noelia Bernardo-GarcíaDepartment of Crystallography & Structural Biology, Institute of Physical-Chemistry "Rocasolano", CSIC, Madrid 28006, Spain.
Alzoray Rojas-AltuveDepartment of Crystallography & Structural Biology, Institute of Physical-Chemistry "Rocasolano", CSIC, Madrid 28006, Spain.
Javier KlettCentro de Biología Molecular Severo Ochoa, CSIC, Madrid 28049, Spain.
Antonio MorrealeCentro de Biología Molecular Severo Ochoa, CSIC, Madrid 28049, Spain.
Juan A HermosoDepartment of Crystallography & Structural Biology, Institute of Physical-Chemistry "Rocasolano", CSIC, Madrid 28006, Spain.
Felipe CavaDepartment of Molecular Biology and Laboratory for Molecular Infection Medicine Sweden, Umeå Centre for Microbial Research, Umeå University, Umeå, Sweden.
Instituto de Química Física Blas Cabrera · ESCentro de Biología Molecular Severo Ochoa · ESUmeå University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Broad-spectrum amino acid racemases (Bsrs) enable bacteria to generate non-canonical D-amino acids (NCDAAs), whose roles and impact on microbial physiology, including modulation of cell wall structure and dissolution of biofilms, are just beginning to be appreciated. Here we used a diverse array of structural, biochemical and molecular simulation studies to define and characterize how BsrV is post-translationally regulated. We discovered that contrary to

Indexed as

Ala-R, Alanine RacemaseBsr, Broad-spectrum RacemaseBsrVDAA, D-Amino AcidsDAAO, D-Amino Acid OxidaseFDAA, 1-fluoro-2-4-dinitrophenyl-5-L-alanineGlu-R, Glutamate RacemaseG, N-acetyl-glucosamineHPLC, High Performance Liquid ChromatographyLAA, L-Amino Acidsm-DAP, l,d-DiaminopimelateM, N-acetyl-muramic acidNCDAANCDAA, Non-Canonical D-Amino AcidsNegative feedback loopPeptidoglycanSDS, Sodium Dodecyl SulfateTEV, Tobacco Etch VirusVibrio cholera

Identifiers

PMID33680355
PMCPMC7890096
OpenAlexW3124947936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.