Evidence map›Paper›PMID 33680353›Full record

ReviewComputational and structural biotechnology journal2021

Machine learning applications in microbial ecology, human microbiome studies, and environmental monitoring.

Ryan B Ghannam, Stephen M Techtmann

Abstract readReview
In one paragraph

Review in Computational and structural biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. A genomic view of Earth's biomes.Nature reviews. Genetics · 2026
    Review
  13. Review
  14. Decoding the rhizosphere microbiome againstFrontiers in microbiomes · 2026
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ryan B GhannamDepartment of Biological Sciences, Michigan Technological University, Houghton MI, United States.
Stephen M TechtmannDepartment of Biological Sciences, Michigan Technological University, Houghton MI, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advances in nucleic acid sequencing technology have enabled expansion of our ability to profile microbial diversity. These large datasets of taxonomic and functional diversity are key to better understanding microbial ecology. Machine learning has proven to be a useful approach for analyzing microbial community data and making predictions about outcomes including human and environmental health. Machine learning applied to microbial community profiles has been used to predict disease states in human health, environmental quality and presence of contamination in the environment, and as trace evidence in forensics. Machine learning has appeal as a powerful tool that can provide deep insights into microbial communities and identify patterns in microbial community data. However, often machine learning models can be used as black boxes to predict a specific outcome, with little understanding of how the models arrived at predictions. Complex machine learning algorithms often may value higher accuracy and performance at the sacrifice of interpretability. In order to leverage machine learning into more translational research related to the microbiome and strengthen our ability to extract meaningful biological information, it is important for models to be interpretable. Here we review current trends in machine learning applications in microbial ecology as well as some of the important challenges and opportunities for more broad application of machine learning to understanding microbial communities.

Indexed as

16S rRNAANN, Artificial Neural NetworksASV, Amplicon Sequence VariantAUC, Area Under the CurveForensicsGB, Gradient BoostingMachine learningMarker genesMetagenomicsML, Machine LearningPCoA, Principal Coordinate AnalysisRF, Random ForestsROC, Receiver Operating CharacteristicSML, Supervised Machine LearningSVM, Support Vector MachinestSNE, t-distributed Stochastic Neighbor EmbeddingUSML, Unsupervised Machine Learning

Identifiers

PMID33680353
PMCPMC7892807

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.