Evidence map›Paper›PMID 33680019›Full record

ArticleIranian journal of pharmaceutical research : IJPR2020

Synthesis and Bioactivity of a Cyclopolypeptide from Caribbean Marine Sponge.

Rajiv Dahiya, Stacy Rampersad, Terry G Ramnanansingh, Komalpreet Kaur, Ramninder Kaur, Rita Mourya, Suresh V Chennupati, Richard Fairman, Nigel K Jalsa, Ajay Sharma and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of pharmaceutical research : IJPR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Therapeutic Potential of Stylissatin A and Related Cyclic Peptides From Marine Sponges.Journal of peptide science : an official publication of the European Peptide Society · 2025
    Review
  3. Review
  4. The Contribution of Human Antimicrobial Peptides to Fungi.International journal of molecular sciences · 2025
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Rajiv DahiyaLaboratory of Peptide Research and Development, School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago.
Stacy RampersadLaboratory of Peptide Research and Development, School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago.
Terry G RamnanansinghLaboratory of Peptide Research and Development, School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago.
Komalpreet KaurDepartment of Pharmaceutical Chemistry, GHG Khalsa College of Pharmacy, Gurusar Sadhar, Ludhiana, Punjab, India.
Ramninder KaurDepartment of Pharmaceutical Chemistry, GHG Khalsa College of Pharmacy, Gurusar Sadhar, Ludhiana, Punjab, India.
Rita MouryaSchool of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Suresh V ChennupatiDepartment of Pharmacy, College of Medical and Health Sciences, Wollega University, Nekemte, Ethiopia.
Richard FairmanDepartment of Chemistry, Faculty of Science and Technology, The University of the West Indies, St. Augustine, Trinidad and Tobago.
Nigel K JalsaDepartment of Chemistry, Faculty of Science and Technology, The University of the West Indies, St. Augustine, Trinidad and Tobago.
Ajay SharmaDepartment of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi, India.
Shivkanya FuloriaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, AIMST University, Semeling, Bedong, Kedah, Malaysia.
Neeraj Kumar FuloriaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, AIMST University, Semeling, Bedong, Kedah, Malaysia.
University of the West Indies · TTAIMST University · MYDelhi Pharmaceutical Science and Research University · INUniversity of Gondar · ETWollega University · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthesis of a natural proline-rich cyclopolypeptide - rolloamide A was carried out by coupling of tri- and tetrapeptide units Boc-Phe-Pro-Val-OMe and Boc-Pro-Leu-Pro-Ile-OMe after proper deprotection at carboxyl and amino terminals using carbodiimide chemistry in alkaline environment followed by cyclization of linear heptapeptide segment in the presence of base. The structure of synthesized peptide was confirmed by spectral techniques including FTIR,

Indexed as

Anthelmintic activityAntibacterial activityAntifungal activityCyclic heptapeptideCyclizationRolloamide ASolution-phase peptide synthesis

Identifiers

PMID33680019
PMCPMC7757994
OpenAlexW3112587755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.