Evidence map›Paper›PMID 33679876›Full record

ArticleFrontiers in genetics2021

Whole-Exome Sequencing and hiPSC Cardiomyocyte Models Identify

Marguerite R Irvin, Praful Aggarwal, Steven A Claas, Lisa de las Fuentes, Anh N Do, C Charles Gu, Andrea Matter, Benjamin S Olson, Amit Patki, Karen Schwander and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Genes, environment, and African ancestry in cardiometabolic disorders.Trends in endocrinology and metabolism: TEM · 2023
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 1 country.

Marguerite R IrvinDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Praful AggarwalDepartment of Pediatrics, Children's Research Institute, Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI, United States.
Steven A ClaasCollege of Public Health, University of Kentucky, Lexington, KY, United States.
Lisa de las FuentesCardiovascular Division, Department of Medicine and Division of Biostatistics, Washington University, St. Louis, MO, United States.
Anh N DoDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, United States.
C Charles GuDivision of Biostatistics, Washington University, St. Louis, MO, United States.
Andrea MatterDepartment of Pediatrics, Children's Research Institute, Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI, United States.
Benjamin S OlsonDepartment of Pediatrics, Children's Research Institute, Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI, United States.
Amit PatkiDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, United States.
Karen SchwanderDivision of Biostatistics, Washington University, St. Louis, MO, United States.
Joshua D SmithDepartment of Genome Sciences, University of Washington, Seattle, WA, United States.
Vinodh SrinivasasainagendraDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, United States.
Hemant K TiwariDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, United States.
Amy J TurnerDepartment of Pediatrics, Children's Research Institute, Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI, United States.
Deborah A NickersonDepartment of Genome Sciences, University of Washington, Seattle, WA, United States.
Dabeeru C RaoDivision of Biostatistics, Washington University, St. Louis, MO, United States.
Ulrich BroeckelDepartment of Pediatrics, Children's Research Institute, Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI, United States.
Donna K ArnettCollege of Public Health, University of Kentucky, Lexington, KY, United States.
University of Alabama at Birmingham · USWashington University in St. Louis · USChildren's Hospital of Wisconsin · USMedical College of Wisconsin · USUniversity of Kentucky · USUniversity of Washington · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
HYPERGEN: GENETICS OF LEFT VENTRICULAR HYPERTROPHYR01HL055673 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ARNETT, DONNA K · 1996 to 2016
$18.1M
Functional GWAS for LVH using iPS-derived Cardiomyocytes: The HyperGEN ciPS StudU01HL107437 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI BROECKEL, ULRICH, BURKE, THOMAS J · 2011 to 2015
$6.1M
Genetics of cardiomyocyte and cardiac matrix interaction: The HyperGen iPSC StudyR01HL125580 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI BROECKEL, ULRICH, WEIHRAUCH, DOROTHEE · 2016 to 2019
$2.6M
NHLBI NIH HHS R01 HL055673NHLBI NIH HHS R01 HL125580NHLBI NIH HHS U01 HL107437NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

African-Americancardiomyocyte modelechocardiographexome sequencinghypertensionleft ventricular hypertrophy

Identifiers

PMID33679876
PMCPMC7933688
OpenAlexW3130444170

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.