Evidence map›Paper›PMID 33679733›Full record

ArticleFrontiers in immunology2021

Characterization of an Antiviral Component in Human Seminal Plasma.

Ran Chen, Wenjing Zhang, Maolei Gong, Fei Wang, Han Wu, Weihua Liu, Yunxiao Gao, Baoxing Liu, Song Chen, Wei Lu and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Innate Antiviral Defense of the Male Reproductive System.Advances in experimental medicine and biology · 2025
    Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Ran ChenInstitute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Wenjing ZhangInstitute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Maolei GongInstitute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Fei WangInstitute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Han WuDepartment of Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Weihua LiuInstitute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Yunxiao GaoDepartment of Andrology, China-Japan Friendship Hospital, Beijing, China.
Baoxing LiuDepartment of Andrology, China-Japan Friendship Hospital, Beijing, China.
Song ChenScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China.
Wei LuScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China.
Xiaoqin YuInstitute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Aijie LiuInstitute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Ruiqin HanInstitute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Yongmei ChenInstitute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Daishu HanInstitute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNChina-Japan Friendship Hospital · CNGuangzhou University of Chinese Medicine · CNShenzhen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous types of viruses have been found in human semen, which raises concerns about the sexual transmission of these viruses. The overall effect of semen on viral infection and transmission have yet to be fully investigated. In the present study, we aimed at the effect of seminal plasma (SP) on viral infection by focusing on the mumps viral (MuV) infection of HeLa cells. MuV efficiently infected HeLa cells

Indexed as

AnimalsAntiviral AgentsCell Line, TumorCells, CulturedChlorocebus aethiopsEpithelial CellsHeLa CellsHost-Pathogen InteractionsHumansMaleMiceMice, Inbred C57BLMumps virusSemenVero CellsVirusesAntiviral Agentsantiviral factormumps virusprostate fluidseminal plasmasexual transmission

Identifiers

PMID33679733
PMCPMC7933687
OpenAlexW3131838300

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.