Evidence map›Paper›PMID 33679707›Full record

ArticleFrontiers in immunology2020

Memory B-Cell Responses Against Merozoite Antigens After Acute

Peter Jahnmatz, Christopher Sundling, Victor Yman, Linnea Widman, Muhammad Asghar, Klara Sondén, Christine Stenström, Christian Smedman, Francis Ndungu, Niklas Ahlborg and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Differences in phenotype between long-lived memory B cells againstbioRxiv : the preprint server for biology · 2024
    Article
  5. Important Considerations for ELISpot Validation.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  6. Article
  7. Article
  8. Frontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Peter JahnmatzDivision of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet and Center for Molecular Medicine, Stockholm, Sweden.
Christopher SundlingDivision of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet and Center for Molecular Medicine, Stockholm, Sweden.
Victor YmanDivision of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet and Center for Molecular Medicine, Stockholm, Sweden.
Linnea WidmanDivision of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Muhammad AsgharDivision of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet and Center for Molecular Medicine, Stockholm, Sweden.
Klara SondénDivision of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet and Center for Molecular Medicine, Stockholm, Sweden.
Christine StenströmDepartment of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.
Christian SmedmanMabtech AB, Nacka Strand, Sweden.
Francis NdunguDivision of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet and Center for Molecular Medicine, Stockholm, Sweden.
Niklas AhlborgMabtech AB, Nacka Strand, Sweden.
Anna FärnertDivision of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet and Center for Molecular Medicine, Stockholm, Sweden.
Karolinska Institutet · SEKarolinska University Hospital · SEMabtech (Sweden) · SEKenya Medical Research Institute · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Memory B cells (MBCs) are believed to be important for the maintenance of immunity to malaria, and these cells need to be explored in the context of different parasite antigens and their breadth and kinetics after natural infections. However, frequencies of antigen-specific MBCs are low in peripheral blood, limiting the number of antigens that can be studied, especially when small blood volumes are available. Here, we developed a multiplexed reversed B-cell FluoroSpot assay capable of simultaneously detecting MBCs specific for the four

Indexed as

AdultAntibodies, ProtozoanAntigens, ProtozoanB-LymphocytesEnzyme-Linked Immunospot AssayFemaleHumansImmunologic MemoryMalaria, FalciparumMaleMerozoitesAntibodies, ProtozoanAntigens, ProtozoanantibodyFluoroSpotmemory B-cellP. falciparum malariarecombinant proteins

Identifiers

PMID33679707
PMCPMC7928423
OpenAlexW3129891564

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.