Evidence map›Paper›PMID 33679694›Full record

ArticleFrontiers in immunology2020

Tolerogenic Effect Elicited by Protein Fraction Derived From Different Formulas for Dietary Treatment of Cow's Milk Allergy in Human Cells.

Lorella Paparo, Gianluca Picariello, Cristina Bruno, Laura Pisapia, Valentina Canale, Antonietta Sarracino, Rita Nocerino, Laura Carucci, Linda Cosenza, Tommaso Cozzolino and 1 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Macronutrients as Regulators of Intestinal Epithelial Permeability: Where Do We Stand?Comprehensive reviews in food science and food safety · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Lorella PaparoDepartment of Translational Medical Science, University of Naples "Federico II", Naples, Italy.
Gianluca PicarielloInstitute of Food Sciences, National Research Council (CNR), Avellino, Italy.
Cristina BrunoDepartment of Translational Medical Science, University of Naples "Federico II", Naples, Italy.
Laura PisapiaDepartment of Translational Medical Science, University of Naples "Federico II", Naples, Italy.
Valentina CanaleDepartment of Translational Medical Science, University of Naples "Federico II", Naples, Italy.
Antonietta SarracinoDepartment of Translational Medical Science, University of Naples "Federico II", Naples, Italy.
Rita NocerinoDepartment of Translational Medical Science, University of Naples "Federico II", Naples, Italy.
Laura CarucciDepartment of Translational Medical Science, University of Naples "Federico II", Naples, Italy.
Linda CosenzaDepartment of Translational Medical Science, University of Naples "Federico II", Naples, Italy.
Tommaso CozzolinoDepartment of Translational Medical Science, University of Naples "Federico II", Naples, Italy.
Roberto Berni CananiDepartment of Translational Medical Science, University of Naples "Federico II", Naples, Italy.
University of Naples Federico II · ITCeinge Biotecnologie Avanzate (Italy) · ITInstitute of Food Science · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several formulas are available for the dietary treatment of cow's milk allergy (CMA). Clinical data suggest potentially different effect on immune tolerance elicited by these formulas. We aimed to comparatively evaluate the tolerogenic effect elicited by the protein fraction of different formulas available for the dietary treatment of CMA. Five formulas were compared: extensively hydrolyzed whey formula (EHWF), extensively hydrolyzed casein formula (EHCF), hydrolyzed rice formula (HRF), soy formula (SF), and amino acid-based formula (AAF). The formulas were reconstituted in water according to the manufacturer's instructions and subjected to an

Indexed as

Immune ToleranceInfant FormulaAmino AcidsAnimalsCaco-2 CellsCaseinsCytokinesElectric ImpedanceEnterocytesEpigenesis, GeneticForkhead Transcription FactorsHumansInfantIntestinal MucosaMilk HypersensitivityOryzaAmino Acidscasein hydrolysateCaseinsCytokinesForkhead Transcription FactorsFOXP3 protein, humanProtein HydrolysatesSoybean ProteinsWhey Proteinsamino acid formulaextensively hydrolyzed casein formulaextensively hydrolyzed whey formulagut barrierhypoallergenic formulasimmune tolerancerice formulasoy formula

Identifiers

PMID33679694
PMCPMC7928417
OpenAlexW3131545022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.