ReviewFrontiers in neurology2021
Skeletal Muscle in Cerebral Palsy: From Belly to Myofibril.
Review in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06330922 (Muscle-tendon Pathology, Metabolic Dysregulation and Chronic Inflammation in Adolescents and Young Adults With Moderate to Severe Spastic Cerebral Palsy), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Muscle-tendon Pathology, Metabolic Dysregulation and Chronic Inflammation in Adolescents and Young Adults With Moderate to Severe Spastic Cerebral Palsy
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Resistance or power training to enhance lower limb muscle morphology in ambulatory children with cerebral palsy? A focused systematic review with meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Effects of progressive functional ankle exercises in spastic cerebral palsy, plantarflexors versus dorsiflexors: a randomized trial.Turkish journal of medical sciences · 2023Trial
- Acute Effects of Static and Proprioceptive Neuromuscular Facilitation Stretching of the Plantar Flexors on Ankle Range of Motion and Muscle-Tendon Behavior in Children with Spastic Cerebral Palsy-A Randomized Clinical Trial.International journal of environmental research and public health · 2022Trial
- Observational
- Exercise-induced fatigability is exacerbated amongst older adults with cerebral palsy compared to younger counterparts.European journal of applied physiology · 2026Article
- Three-year outcomes of repeated botulinum neurotoxin A injections to the lower extremities in young children with spastic cerebral palsy in GMFCS levels I to III.Developmental medicine and child neurology · 2026Observational
- Quantification of muscle morphology and stiffness in spastic hemiplegic cerebral palsy versus typically developing controls using magnetic resonance elastography.Clinical biomechanics (Bristol, Avon) · 2026Article
- Microscopic and molecular aspects of skeletal muscle alterations in cerebral palsy.Developmental medicine and child neurology · 2026Review
- Morphological and Biochemical Abnormalities of Gracilis Muscle from Children with Cerebral Palsy.Journal of functional morphology and kinesiology · 2026Article
- Upper-limb range of motion in children with cerebral palsy treated with botulinum neurotoxin: a population-based cohort study.BMC musculoskeletal disorders · 2026Article
- Sonomyography accurately captures joint kinematics during volitional and electrically stimulated motion in healthy adults and an individual with cerebral palsy.Journal of neuroengineering and rehabilitation · 2025Article
- Collagenase treatment does not impair fiber contractile function in muscle biopsies from children with cerebral palsy.Physiological reports · 2025Article
- Estimating the contribution of musculoskeletal impairments to altered gait kinematics in children with cerebral palsy using predictive simulations.Journal of neuroengineering and rehabilitation · 2025Article
- Impact of Wrist and Finger Extension on Passive Joint Torques and Their Association with Forearm Flexor Muscle Structure in Hemiparetic Cerebral Palsy: Early Findings.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025Article
- Exploratory Evaluation for Functional Changes of Six-Month Systematic Non-Invasive Electrical Stimulation in a Whole-Body Suit on Children with Cerebral Palsy GMFCS III-V.Neurology international · 2025Article
- Enduring effects of acute prenatal ischemia in rat soleus muscle, and protective role of erythropoietin.Journal of muscle research and cell motility · 2025Article
- Effects of a therapeutic suit based on myofascial meridians on postural control and balance in children with cerebral palsy: a multiple-baseline, single-subject study.Frontiers in pediatrics · 2025Article
- Botulinum Toxin's Effects on Muscle Tone and Joint Mobility in Children with Congenital Zika Syndrome - A Case Series.Revista brasileira de ortopedia · 2024Article
- Narrative Review of the Theoretical-Methodological Foundations of the TREINI Program.Children (Basel, Switzerland) · 2024Review
- Muscle in children with cerebral palsy: current evidence, knowledge gaps, and emerging research opportunities : Focus on Cerebral Palsy.Pediatric research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review will provide a comprehensive, up-to-date review of the current knowledge regarding the pathophysiology of muscle contractures in cerebral palsy. Although much has been known about the clinical manifestations of both dynamic and static muscle contractures, until recently, little was known about the underlying mechanisms for the development of such contractures. In particular, recent basic science and imaging studies have reported an upregulation of collagen content associated with muscle stiffness. Paradoxically, contractile elements such as myofibrils have been found to be highly elastic, possibly an adaptation to a muscle that is under significant
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.