Evidence map›Paper›PMID 33679437›Full record

ReviewFrontiers in physiology2021

Rafael Dariolli, Chiara Campana, Amy Gutierrez, Eric A Sobie

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rafael DariolliDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Chiara CampanaDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Amy GutierrezDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Eric A SobieDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Icahn School of Medicine at Mount Sinai · US

Funding

Multiscale modeling to map cardiac electrophysiology between speciesU01HL136297 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHRISTINI, DAVID J., SOBIE, ERIC A · 2017 to 2021
$3.2M
HLS-Cardiac Safety AI Trained Human Heart and Micro Heart ModelR44HL139248 · NHLBI · INVIVOSCIENCES, INC. · PI WAKATSUKI, TETSURO · 2018 to 2020
$2.1M
NHLBI NIH HHS R44 HL139248NHLBI NIH HHS U01 HL136297
6 · The paper itself

Abstract

The rapid dissemination of SARS-CoV-2 has made COVID-19 a tremendous social, economic, and health burden. Despite the efforts to understand the virus and treat the disease, many questions remain unanswered about COVID-19 mechanisms of infection and progression. Severe Acute Respiratory Syndrome (SARS) infection can affect several organs in the body including the heart, which can result in thromboembolism, myocardial injury, acute coronary syndromes, and arrhythmias. Numerous cardiac adverse events, from cardiomyocyte death to secondary effects caused by exaggerated immunological response against the virus, have been clinically reported. In addition to the disease itself, repurposing of treatments by using "off label" drugs can also contribute to cardiotoxicity. Over the past several decades, animal models and more recently, stem cell-derived cardiomyocytes have been proposed for studying diseases and testing treatments

Indexed as

cardiomyocytesCOVID-19hiPSC-CMsmodelingpluripotent stem cellsSARS-CoV-2

Identifiers

PMID33679437
PMCPMC7925402
OpenAlexW3129911707

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.