Evidence map›Paper›PMID 33679385›Full record

ArticleFrontiers in pharmacology2020

Neuroprotective Role of GLP-1 Analog for Retinal Ganglion Cells via PINK1/Parkin-Mediated Mitophagy in Diabetic Retinopathy.

Huan-Ran Zhou, Xue-Fei Ma, Wen-Jian Lin, Ming Hao, Xin-Yang Yu, Hong-Xue Li, Cheng-Ye Xu, Hong-Yu Kuang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Huan-Ran ZhouDepartment of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Xue-Fei MaDepartment of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Wen-Jian LinDepartment of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Ming HaoDepartment of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Xin-Yang YuDepartment of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Hong-Xue LiDepartment of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Cheng-Ye XuDepartment of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Hong-Yu KuangDepartment of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Harbin Medical University · CNFirst Affiliated Hospital of Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GLP-1 analogs have been widely used to treat patients with type 2 diabetes in recent years and studies have found that GLP-1 analogs have multiple organ benefits. However, the role of GLP-1 analogs in diabetic retinopathy (DR), a common complication of diabetes mellitus (DM), remains controversial. Retinal ganglion cells (RGCs) are the only afferent neurons responsible for transmitting visual information to the visual center and are vulnerable in the early stage of DR. Protection of RGC is vital for visual function. The incretin glucagon-like peptide-1 (GLP-1), which is secreted by L-cells after food ingestion, could lower blood glucose level through stimulating the release of insulin. In the present study, we evaluated the effects of GLP-1 analog on RGCs both

Indexed as

diabetic retinopathyGLP-1GLP-1 analogmitophagyretinal ganglion cell

Identifiers

PMID33679385
PMCPMC7928389
OpenAlexW3131987965

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.