ArticleFrontiers in aging neuroscience2021
Loss of Integrity of Corpus Callosum White Matter Hyperintensity Penumbra Predicts Cognitive Decline in Patients With Subcortical Vascular Mild Cognitive Impairment.
Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Association between white matter alterations and domain-specific cognitive impairment in cerebral small vessel disease: A meta-analysis of diffusion tensor imaging.Frontiers in aging neuroscience · 2022Pooled it
- Plasma GFAP and NLRP3 Associate with Cognitive Impairment After Recent Small Subcortical Infarct via Periventricular White Matter Hyperintensity.CNS neuroscience & therapeutics · 2026Article
- Deep Learning for Classifying and Cognitive Profiling of Subcortical Vascular Cognitive Impairment.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- Birefringence microscopy enables rapid, label-free quantification of myelin debris following induced cortical injury.Neurophotonics · 2025Article
- A software ecosystem for brain tractometry processing, analysis, and insight.PLoS computational biology · 2025Article
- Damage to white matter networks resulting from small vessel disease and the effects on cognitive function.Scientific reports · 2025Article
- Cerebral white matter damage in patients with end-stage kidney disease associates with cognitive impairment.Clinical kidney journal · 2025Article
- Cognitive Impairment in Cerebral Small Vessel Disease Is Associated with Corpus Callosum Microstructure Changes Based on Diffusion MRI.Diagnostics (Basel, Switzerland) · 2024Article
- Intermittent Metabolic Switching and Vascular Cognitive Impairment.Journal of obesity & metabolic syndrome · 2024Review
- Diffusion tensor imaging in cerebral small vessel disease applications: opportunities and challenges.Frontiers in neuroscience · 2024Review
- Associations between cerebral blood flow and progression of white matter hyperintensities.Frontiers in neuroimaging · 2024Article
- Clinical and cognitive correlates tractography analysis in patients with white matter hyperintensity of vascular origin.Frontiers in neuroscience · 2023Article
- Alzheimer's and vascular disease classification using regional texture biomarkers in FLAIR MRI.NeuroImage. Clinical · 2023Article
- Multiscale functional connectome abnormality predicts cognitive outcomes in subcortical ischemic vascular disease.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Altered Microstructural Changes Detected by Diffusion Kurtosis Imaging in Patients With Cognitive Impairment After Acute Cerebral Infarction.Frontiers in neurology · 2022Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Loss of white matter (WM) integrity contributes to subcortical vascular mild cognitive impairment (svMCI). Diffusion tensor imaging (DTI) has revealed damage beyond the area of WM hyperintensity (WMH) including in normal-appearing WM (NAWM); however, the functional significance of this observation is unclear. To answer this question, in this study we investigated the relationship between microstructural changes in the WMH penumbra (WMH-P) and cognitive function in patients with svMCI by regional tract-based analysis. A total of 111 patients with svMCI and 72 patients with subcortical ischemic vascular disease (SIVD) without cognitive impairment (controls) underwent DTI and neuropsychological assessment. WMH burden was determined before computing mean values of fractional anisotropy (FA) and mean diffusivity (MD) within WMHs and WMH-Ps. Pearson's partial correlations were used to assess the relationship between measurements showing significant intergroup differences and composite
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