ArticleFrontiers in cellular neuroscience2021
Sensory Detection by the Vomeronasal Organ Modulates Experience-Dependent Social Behaviors in Female Mice.
Article in Frontiers in cellular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Loss of the endoplasmic reticulum protein canopy 1 disrupts the function and circuit organization of V2R-expressing vomeronasal sensory neurons.Development (Cambridge, England) · 2026Article
- Type 2 vomeronasal receptor-A4 subfamily: Potential predator sensors in mice.Genesis (New York, N.Y. : 2000) · 2024Review
- Sensing and avoiding sick conspecifics requires Gαi2BMC biology · 2023Article
- Mother-Young Bonding: Neurobiological Aspects and Maternal Biochemical Signaling in Altricial Domesticated Mammals.Animals : an open access journal from MDPI · 2023Review
- Behavioral evidence of the functional interaction between the main and accessory olfactory system suggests a large olfactory system with a high plastic capability.Frontiers in neuroanatomy · 2023Review
- Presynaptic GABAFrontiers in cellular neuroscience · 2023Article
- Article
- Notch signaling determines cell-fate specification of the two main types of vomeronasal neurons of rodents.Development (Cambridge, England) · 2022Article
- Deletion of neural estrogen receptor alpha induces sex differential effects on reproductive behavior in mice.Communications biology · 2022Article
- Sex separation unveils the functional plasticity of the vomeronasal organ in rabbits.Frontiers in molecular neuroscience · 2022Article
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Authors and funding
8 authors.
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Abstract
In mice, social behaviors are largely controlled by the olfactory system. Pheromone detection induces naïve virgin females to retrieve isolated pups to the nest and to be sexually receptive to males, but social experience increases the performance of both types of innate behaviors. Whether animals are intrinsically sensitive to the smell of conspecifics, or the detection of olfactory cues modulates experience for the display of social responses is currently unclear. Here, we employed mice with an olfactory-specific deletion of the G protein Gαi2, which partially eliminates sensory function in the vomeronasal organ (VNO), to show that social behavior in female mice results from interactions between intrinsic mechanisms in the vomeronasal system and experience-dependent plasticity. In pup- and sexually-naïve females, Gαi2 deletion elicited a reduction in pup retrieval behavior, but not in sexual receptivity. By contrast, experienced animals showed normal maternal behavior, but the experience-dependent increase in sexual receptivity was incomplete. Further, lower receptivity was accompanied by reduced neuronal activity in the anterior accessory olfactory bulb and the rostral periventricular area of the third ventricle. Therefore, neural mechanisms utilize intrinsic sensitivity in the mouse vomeronasal system and enable plasticity to display consistent social behavior.
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