Evidence map›Paper›PMID 33679328›Full record

ReviewFrontiers in cellular neuroscience2021

Emerging Perspectives on Dipeptide Repeat Proteins in C9ORF72 ALS/FTD.

Alexander Schmitz, João Pinheiro Marques, Irina Oertig, Niran Maharjan, Smita Saxena

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cellular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 68 citations in OpenAlex.

  1. Review
  2. Intrathecal (GActa neuropathologica communications · 2026
    Article
  3. Article
  4. Intrathecal (GbioRxiv : the preprint server for biology · 2026
    Article
  5. Brain communications · 2026
    Article
  6. Review
  7. Article
  8. ACS omega · 2025
    Article
  9. Article
  10. Review
  11. G-Quadruplex Structures Formed by Human Telomere andInternational journal of molecular sciences · 2025
    Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Alexander SchmitzDepartment of Neurology, Center for Experimental Neurology, Inselspital University Hospital, Bern, Switzerland.
João Pinheiro MarquesDepartment of Neurology, Center for Experimental Neurology, Inselspital University Hospital, Bern, Switzerland.
Irina OertigDepartment of Neurology, Center for Experimental Neurology, Inselspital University Hospital, Bern, Switzerland.
Niran MaharjanDepartment of Neurology, Center for Experimental Neurology, Inselspital University Hospital, Bern, Switzerland.
Smita SaxenaDepartment of Neurology, Center for Experimental Neurology, Inselspital University Hospital, Bern, Switzerland.
University Hospital of Bern · CHUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is a hexanucleotide expansion in the chromosome 9 open reading frame 72 gene (

Indexed as

amyotrophic lateral scelerosisC9ORF72 ALS/FTDdipeptide repeat proteins (DPRs)motor neuronneurodegenerationRAN translation

Identifiers

PMID33679328
PMCPMC7930069
OpenAlexW3131420719

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.