Evidence map›Paper›PMID 33679314›Full record

ArticleFrontiers in neuroscience2021

Repetitive Peripheral Magnetic Stimulation of Wrist Extensors Enhances Cortical Excitability and Motor Performance in Healthy Individuals.

Mitsuhiro Nito, Natsuki Katagiri, Kaito Yoshida, Tadaki Koseki, Daisuke Kudo, Shigehiro Nanba, Shigeo Tanabe, Tomofumi Yamaguchi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mitsuhiro NitoDepartment of Anatomy and Structural Science, Yamagata University School of Medicine, Yamagata, Japan.
Natsuki KatagiriGraduate School of Health Sciences, Yamagata Prefectural University of Health Sciences, Yamagata, Japan.
Kaito YoshidaGraduate School of Health Sciences, Yamagata Prefectural University of Health Sciences, Yamagata, Japan.
Tadaki KosekiGraduate School of Health Sciences, Yamagata Prefectural University of Health Sciences, Yamagata, Japan.
Daisuke KudoGraduate School of Health Sciences, Yamagata Prefectural University of Health Sciences, Yamagata, Japan.
Shigehiro NanbaGraduate School of Health Sciences, Yamagata Prefectural University of Health Sciences, Yamagata, Japan.
Shigeo TanabeFaculty of Rehabilitation, School of Health Sciences, Fujita Health University, Toyoake-shi, Japan.
Tomofumi YamaguchiGraduate School of Health Sciences, Yamagata Prefectural University of Health Sciences, Yamagata, Japan.
Yamagata Prefectural University of Health Sciences · JPFujita Health University · JPYamagata University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repetitive peripheral magnetic stimulation (rPMS) may improve motor function following central nervous system lesions, but the optimal parameters of rPMS to induce neural plasticity and mechanisms underlying its action remain unclear. We examined the effects of rPMS over wrist extensor muscles on neural plasticity and motor performance in 26 healthy volunteers. In separate experiments, the effects of rPMS on motor evoked potentials (MEPs), short-interval intracortical inhibition (SICI), intracortical facilitation (ICF), direct motor response (M-wave), Hoffmann-reflex, and ballistic wrist extension movements were assessed before and after rPMS. First, to examine the effects of stimulus frequency, rPMS was applied at 50, 25, and 10 Hz by setting a fixed total number of stimuli. A significant increase in MEPs of wrist extensors was observed following 50 and 25 Hz rPMS, but not 10 Hz rPMS. Next, we examined the time required to induce plasticity by increasing the number of stimuli, and found that at least 15 min of 50 and 25 Hz rPMS was required. Based on these parameters, lasting effects were evaluated following 15 min of 50 or 25 Hz rPMS. A significant increase in MEP was observed up to 60 min following 50 and 25 Hz rPMS; similarly, an attenuation of SICI and enhancement of ICF were also observed. The maximal M-wave and Hoffmann-reflex did not change, suggesting that the increase in MEP was due to plastic changes at the motor cortex. This was accompanied by increasing force and electromyograms during wrist ballistic extension movements following 50 and 25 Hz rPMS. These findings suggest that 15 min of rPMS with 25 Hz or more induces an increase in cortical excitability of the relevant area rather than altering the excitability of spinal circuits, and has the potential to improve motor output.

Indexed as

corticospinal tractintracortical circuitsplasticityrehabilitationspinal networksupper extremity

Identifiers

PMID33679314
PMCPMC7930341
OpenAlexW3130956148

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.