Evidence map›Paper›PMID 33679268›Full record

ArticleContrast media & molecular imaging2021

Zinc Preconditioning Provides Cytoprotection following Iodinated Contrast Media Exposure in In Vitro Models.

Marlon Perera, Joseph Ischia, Damien Bolton, Arthur Shulkes, Graham S Baldwin, Oneel Patel

Abstract read
In one paragraph

Article in Contrast media & molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Anti-inflammatory effects ofScientific reports · 2025
    Article
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marlon PereraUniversity of Melbourne Department of Surgery, Austin Health, Melbourne, Victoria, Australia.ORCID 0000-0002-1138-6389
Joseph IschiaUniversity of Melbourne Department of Surgery, Austin Health, Melbourne, Victoria, Australia.ORCID 0000-0001-7177-3631
Damien BoltonUniversity of Melbourne Department of Surgery, Austin Health, Melbourne, Victoria, Australia.ORCID 0000-0002-5145-6783
Arthur ShulkesUniversity of Melbourne Department of Surgery, Austin Health, Melbourne, Victoria, Australia.
Graham S BaldwinUniversity of Melbourne Department of Surgery, Austin Health, Melbourne, Victoria, Australia.ORCID 0000-0002-0944-8747
Oneel PatelUniversity of Melbourne Department of Surgery, Austin Health, Melbourne, Victoria, Australia.ORCID 0000-0001-5628-7205

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methods: Normal human proximal renal kidney cells (HK-2) were preconditioned with either increasing doses of ZnCl Results: Contrast media induced a dose-dependent reduction in survival of HK-2 cells. Compared to control, contrast media at 150, 225, and 300 mg I Conclusions: Zinc preconditioning reduces oxidative stress following exposure to radiographic contrast media which in turn results in increased survival of renal cells. Translation of this

Indexed as

AnimalsApoptosisCell LineContrast MediaCytoprotectionHumansIohexolKidneyKidney Tubules, ProximalOxidative StressZincContrast MediaIohexolZinc

Identifiers

PMID33679268
PMCPMC7904368

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.