ArticleJournal of atherosclerosis and thrombosis2021
COVID-19-Related Thrombosis in Japan: Final Report of a Questionnaire-Based Survey in 2020.
Article in Journal of atherosclerosis and thrombosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Impact of the Geriatric Nutritional Risk Index on In-hospital Thrombosis and Mortality in Patients Hospitalized with COVID-19.Internal medicine (Tokyo, Japan) · 2025Article
- Impact of bleeding and thrombosis on outcome of 945 COVID-19 VV-ECMO cases from a German registry.Frontiers in medicine · 2025Article
- Unfractionated Heparin Safety in COVID-19: Incidence and Risks of Bleeding Complications in Japan.Journal of atherosclerosis and thrombosis · 2024Article
- Platelet and large platelet ratios are useful in predicting severity of COVID-19.International journal of hematology · 2024Article
- Characteristics and prognosis of patients with COVID-19 and hematological diseases in Japan: a cross-sectional study.International journal of hematology · 2024Article
- Role of Fibrin Monomer Complex in Coronavirus Disease 2019 for Venous Thromboembolism and the Prognosis.Internal medicine (Tokyo, Japan) · 2023Article
- Venous thromboembolism in an Asian COVID-19 cohort across 3 infection waves-a retrospective observational study.Research and practice in thrombosis and haemostasis · 2023Article
- Thromboembolic Presentations among Patients Hospitalized to the Intensive Care Unit for Coronavirus Disease 2019 (COVID-19) - A Northern Taiwan Single Center Experience.Acta Cardiologica Sinica · 2023Article
- Significant Impact of Age on Mortality and Non-significant Impact of Age on Thrombosis and Major Bleeding in Patients with COVID-19: From the CLOT-COVID Study.Journal of atherosclerosis and thrombosis · 2023Observational
- Thrombotic Mechanism Involving Platelet Activation, Hypercoagulability and Hypofibrinolysis in Coronavirus Disease 2019.International journal of molecular sciences · 2023Review
- Thrombosis and Anticoagulation Strategies in Patients with COVID-19 Including Japanese Perspective.Journal of atherosclerosis and thrombosis · 2023Article
- Risk Factors and Impact on Outcomes of Thrombosis in Patients with COVID-19 in Japan: From the CLOT-COVID Study.Annals of vascular diseases · 2023Article
- Urokinase-type plasminogen activator and plasminogen activator inhibitor-1 complex as a serum biomarker for COVID-19.Frontiers in immunology · 2023Article
- Real-World Management of Pharmacological Thromboprophylactic Strategies for COVID-19 Patients in Japan: From the CLOT-COVID Study.JACC. Asia · 2022Article
- Article
- COVID-19 Severity and Thrombo-Inflammatory Response Linked to Ethnicity.Biomedicines · 2022Article
- The current status of thrombosis and anticoagulation therapy in patients with COVID-19 in Japan: From the CLOT-COVID study.Journal of cardiology · 2022Observational
- Racial and ethnic differences in pharmacotherapy to prevent coronary artery disease and thrombotic events.European heart journal. Cardiovascular pharmacotherapy · 2022Review
- Large-Vessel Occlusion Stroke Treated by Endovascular Thrombectomy in Patient with Coronavirus Disease 2019.Asian journal of neurosurgery · 2022Article
- A novel anticoagulation treatment protocol using unfractionated heparin for coronavirus disease 2019 patients in Japan, 2022.Global health & medicine · 2022Article
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Authors and funding
5 authors.
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Abstract
A questionnaire on COVID-19-related thrombosis in patients hospitalized before Aug 31, 2020, was sent to 399 hospitals throughout Japan. Responses were received from 111 (27.8%) with information on 6,202 COVID-19 patients. Of these, 333 and 56 required ventilation or extracorporeal membrane oxygenation (ECMO), respectively, and 212 died (3.4%). D-dimer levels were measured in 75.0% of the patients, revealing that 9.2% and 7.6% exhibited D-dimer increases of 3-8-fold and ≥8-fold the reference value, respectively. Thrombotic events occurred in 108 patients (1.86% of the 5,807 patients with available data) including symptomatic cerebral infarction in 24, myocardial infarction in 7, deep vein thrombosis in 41, pulmonary thromboembolism in 30, and other thrombotic events in 22. Some patients developed multiple thrombotic events. Thrombosis occurred in 32 patients with mild or moderate COVID-19 severity (0.59% of those with data available) and in 52 patients on ventilation or ECMO (13.5% of severe patients for whom data were available). Thrombosis occurred in 67 patients during worsening clinical condition and in 26 during recovery. Anticoagulant therapy was provided to 893 patients (14.6% of the 6,119 patients with available data), the main reasons being provided as elevated D-dimer levels and worsening clinical condition.
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