Evidence map›Paper›PMID 33678636›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2021

Clinical characteristics of Graves

Juan Mo, Lei Fu, Yixiang Zheng, Shifang Peng

Open access · greenAbstract read
In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Juan MoDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, China. 642533771@qq.com.
Lei FuDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, China.
Yixiang ZhengDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, China.
Shifang PengDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, China. sfp1988@csu.edu.cn.
Central South University · CNXiangya Hospital Central South University · CN

Funding

the Clinical Research Foundation of Xiangya Hospital, Central South University 2016L10the National Natural Science Foundation 81770623 and 81974080the Natural Science Foundation of Hunan Province 2018JJ2657
6 · The paper itself

Abstract

objectivesA variety of causes can lead to cholestasis, however, cholestasis caused by Graves' disease is usually overlooked clinically. Here we analyze the clinical characteristics of Graves' disease associated cholestasis so as to have a better understanding for the disease.

methodsWe retrospectively collected 13 inpatients' data who suffered from the Graves' disease associated cholestasis in the Department of Infectious Disease of Xiangya Hospital from January 2000 to December 2018. The characteristics of the patients' age, gender, liver function, thyroid function, coagulation function, the special cardiac examination, treatment, and follow-up data were analyzed.

resultsThirteen patients, including 10 males and 3 females with the age range from 33 to 55 (median 43) years old presented cholestasis, pruritus, and hypermetabolic symptoms. The levels of total bilirubin (TBIL), direct bilirubin (DBIL), glutamic-pyruvic transferase, glutamic-oxaloacetic transferase, alkaline phosphosphatase, and gamma glutamyl transpeptidase were 170.4-976.7 (median 388.8) µmol/L, 93.2-418.1 (median 199.2) µmol/L, 25.1-182.1 (median 106.4) U/L, 38.2-265.7 (median 59.7) U/L, 105.3-332.0 (median 184.5) U/L, and 20.7-345.1 (median 47.6) U/L, respectively. The levels of free triiodothyronine (FT

conclusionsGraves' disease can cause cholestasis, with the low incidence. The symptoms of cholestasis can be improved or even eradicated with the cure of the Graves' disease. The cholestasis may be idiopathic. For patients with cholestasis and hyperthyroidism, Graves' disease should be considered for differential diagnosis.

Indexed as

CholestasisGraves DiseaseAdultFemaleHumansMaleMiddle AgedRetrospective StudiesThyroid Function TestsThyroxineTriiodothyronineThyroxineTriiodothyroninecholestasisclinical manifestationdiagnosisGraves’ diseaseGraves’ disease associated cholestasistreatment

Identifiers

PMID33678636
PMCPMC10878292
OpenAlexW3135190609

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.