Evidence map›Paper›PMID 33678551›Full record

ReviewTrends in cell biology2021

Balancing ER-Mitochondrial Ca

Jens Loncke, Allen Kaasik, Ilya Bezprozvanny, Jan B Parys, Martijn Kerkhofs, Geert Bultynck

Open access · greenAbstract readReview
In one paragraph

Review in Trends in cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 148 citations in OpenAlex.

  1. Review
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  3. Bone organoids and mitochondrial reprogramming.Journal of orthopaedic translation · 2026
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 4 countries.

Jens LonckeLaboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven Kanker Instituut, KU Leuven, Campus Gasthuisberg O/N-1 B-802, Herestraat 49, BE-3000 Leuven, Belgium.
Allen KaasikInstitute of Biomedicine and Translational Medicine, Department of Pharmacology, University of Tartu, Tartu, Estonia.
Ilya BezprozvannyLaboratory of Molecular Neurodegeneration, Institute of Biomedical Systems and Biotechnologies, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russian Federation; Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX, USA.
Jan B ParysLaboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven Kanker Instituut, KU Leuven, Campus Gasthuisberg O/N-1 B-802, Herestraat 49, BE-3000 Leuven, Belgium.
Martijn KerkhofsLaboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven Kanker Instituut, KU Leuven, Campus Gasthuisberg O/N-1 B-802, Herestraat 49, BE-3000 Leuven, Belgium.
Geert BultynckLaboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven Kanker Instituut, KU Leuven, Campus Gasthuisberg O/N-1 B-802, Herestraat 49, BE-3000 Leuven, Belgium. Electronic address: geert.bultynck@kuleuven.be.
KU Leuven · BEThe University of Texas Southwestern Medical Center · USUniversity of Tartu · EE

Funding

Deranged calcium signaling and polyglutamine expansion disordersR01NS056224 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI BEZPROZVANNY, ILYA B · 2008 to 2020
$3.5M
Calcium signaling and synaptic maintenance in Alzheimers diseaseRF1AG055577 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI BEZPROZVANNY, ILYA B, KAVALALI, EGE T · 2017 to 2017
$3.0M
NIA NIH HHS RF1 AG055577NINDS NIH HHS R01 NS056224
6 · The paper itself

Abstract

Organelles cooperate with each other to control cellular homeostasis and cell functions by forming close connections through membrane contact sites. Important contacts are present between the endoplasmic reticulum (ER), the main intracellular Ca

Indexed as

CalciumCalcium SignalingEndoplasmic ReticulumMitochondriaMitochondrial MembranesCalciumCa(2+) signalingcancercontact sitesgenetic diseasesMAMsneurodegeneration

Identifiers

PMID33678551
PMCPMC8195822
OpenAlexW3134729907

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.